1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: synthesis, characterization and its biological studies

Harikrishna N.; Isloor Arun M.; Ananda K.; Obaid Abdulrahman; Fun Hoong-Kun

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1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: synthesis, characterization and its biological studies

机译：1,3,4-三取代的吡唑轴承为4-（Chromen-2-One）噻唑：合成，表征及其生物学研究

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A new series 3-{2-[N'-(1,3-disubstituted-1H-pyrazol-4-yl-methylene)-hydrazino]-thiazol-4-yl}-chromen-2- one (10a-l) was synthesized by a multi-step reaction. All the synthesized compounds were characterized by IR, NMR, and mass spectral studies, followed by elemental analysis. The newly synthesized thiazole compounds were screened for their in vitro antibacterial and antifungal studies against various microorganisms. Antimicrobial studies carried out by the well diffusion method, showed a very good zone of inhibition for both bacteria (at a range of 20-50 mm diameter) and fungi (at a range of 1030 mm diameter). Minimum Inhibitory Concentration (MIC) required for the 100% inhibition of bacteria and fungi was found to be as low as 15.6 mu g ml(-1) for a few of the synthesized compounds.

机译：新系列3- {2- [n' - （1,3-二取代 - 1H-吡唑-4-基 - 亚甲基）-羟基芳基] -thiazol-4-Y1} - 铬酮-2-一（10A-L）通过多步反应合成。所有合成的化合物的特征在于IR，NMR和质谱研究，然后进行元素分析。将新合成的噻唑化合物筛选用于对各种微生物的体外抗菌和抗真菌研究。通过井扩散方法进行的抗微生物研究，对两种细菌（直径为20-50mm）和真菌（直径为1030mm）的抑制区域非常好的抑制区。对于100％抑制细菌和真菌所需的最小抑制浓度（MIC）对于少数合成的化合物，发现低至15.6μg（-1）。

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《RSC Advances》 |2015年第54期|共12页
作者
Harikrishna N.; Isloor Arun M.; Ananda K.; Obaid Abdulrahman; Fun Hoong-Kun;
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Natl Inst Technol Karnataka Dept Chem Med Chem Lab Mangalore 575025 India;

Natl Inst Technol Karnataka Dept Chem Med Chem Lab Mangalore 575025 India;

Poornaprajna Inst Sci Res Biol Sci Bangalore 562110 Karnataka India;

King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

King Saud Univ Coll Pharm Dept Pharmaceut Chem Riyadh 11451 Saudi Arabia;

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正文语种 eng
中图分类化学;
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1. 1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: synthesis, characterization and its biological studies [J] . Harikrishna N., Isloor Arun M., Ananda K., RSC Advances . 2015,第54期

机译：1,3,4-三取代的吡唑轴承为4-（Chromen-2-One）噻唑：合成，表征及其生物学研究
2. Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing 1,3,4- thiadiazole moiety [J] . Xiaoming Ding1, Zhiwen Zhai2, Luping Lv1, 化学科学与工程前沿：英文版 . 2017,第003期

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1,3,4-Trisubstituted pyrazole bearing a 4-(chromen-2-one) thiazole: synthesis, characterization and its biological studies

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