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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Dietary treatment of fatty liver: High dietary protein content has an antisteatotic and antiobesogenic effect in mice
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Dietary treatment of fatty liver: High dietary protein content has an antisteatotic and antiobesogenic effect in mice

机译：脂肪肝的膳食治疗：高膳食蛋白质含量对小鼠的反问题和抗溶解作用

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摘要

Few studies have assessed the effect of changing ratios of dietary macronutrients on fat accumulation in adipose tissue and organs such as the liver in a 3 x n(n >= 3) factorial design. We investigated the effects of 7 diets from a single manufacturer containing 11-58 en% protein (casein), 0-81 en% carbohydrates (CHO; sucrose, maltro-dextrin-10 and corn starch), and 8-42 en% fat (triheptanoin, olive oil or cocoa butter) in C57BL/6 J mice, a good model for diet-induced obesity and fatty liver. The diets were fed for 3 weeks to wild-type and hyperlipidemic male and female mice. Caloric intake was mainly determined by dietary fat. Body weight, liver lipid and cholesterol content, NF kappa B activation, and fat-pad size decreased only in mice fed a high-protein diet. A high dietary protein:CHO ratio reduced plasma FGF21 concentration, and increased liver PCK1 protein content and plasma triglyceride concentration. The dietary protein:CHO ratio determined hepatic expression of Pckl and Ppargcl a in males, and Fgf21 in females, whereas the dietary CHO:fat ratio determined that of Fasn, Acacal, and Scdl in females. Hepatic glycogen content was determined by all three dietary components. Both hepatic PCK1 and plasma FGF21 correlated strongly and inversely with hepatic TG content, suggesting a key role for PCK1 and increased gluconeogenesis in resolving steatosis with a high-protein diet, with FGF21 expression reflecting declining cell stress. We propose that a diet containing similar to 35 en% protein, 5-10 en% fat, and 55-60 en% carbohydrate will prevent fatty liver in mice without inducing side effects.
机译：很少有研究已经评估了饮食Macronrients比率在脂肪组织和器官中脂肪积累的影响，例如肝脏在3×N（n> = 3）阶段设计中。我们研究了7岁的含有11-58·％蛋白（酪蛋白），0-81烯％碳水化合物（Cho;蔗糖，葡萄糖，糊精-10和玉米淀粉）和8-42升的脂肪的影响（三肽素，橄榄油或可可脂）在C57BL / 6 J小鼠中，饮食诱导肥胖和脂肪肝的良好模型。将饮食饲喂3周至野生型和高脂质血症雄性和女性小鼠。热量摄入主要由膳食脂肪决定。体重，肝脂质和胆固醇含量，NFκB活化，并且脂肪垫尺寸仅在喂养高蛋白质饮食的小鼠中降低。高膳食蛋白质：CHO比降低血浆FGF21浓度，肝PCK1蛋白质含量增加和血浆甘油三酯浓度。膳食蛋白质：CHO比确定了男性中PCK1和PPALGCL A的肝脏表达，而FGF21在雌性中，而饮食CHO：脂肪比确定了女性中的FASN，ACACAL和SCDL。肝糖原含量由所有三种膳食成分测定。肝PCK1和等离子体FGF21两者都与肝TG含量强烈相关，表明PCK1的关键作用和葡甘油生成增加，以通过高蛋白饮食解决脂肪变性，反映细胞胁迫下降。我们提出含有类似于35〜％蛋白的饮食，5-10·％脂肪和55-60·％碳水化合物将防止小鼠脂肪肝脏，而不会诱导副作用。

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