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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker
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Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker

机译：长度非编码RNA AWPPH通过YBX1促进肝细胞癌进展，并用作预后生物标志物

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摘要

Long noncoding RNAs (IncRNAs) have been shown to play important roles in various cancers. However, the clinical significances and biological roles of IncRNAs in hepatocellular carcinoma (HCC) remain largely unknown. In this study, using online-available data sets and quantitative real-time PCR, we identified a novel lncRNA termed lncRNA-AWPPH, which is highly expressed in HCC tissues. Its upregulation is correlated with encapsulation incomplete, microvascular invasion, advanced TNM stage and BCLC stage. Cox proportional hazards regression analysis revealed that high lncRNA-AWPPH expression is an independent prognostic factor for poor recurrence-free and overall survival. Functional experiments showed that overexpression of lncRNA-AWPPH promotes HCC cell proliferation and migration in vitro, and tumor growth and metastasis in vivo. Conversely, depletion of lncRNA-AWPPH has opposite effects on HCC. Mechanistically, IncRNA-AWPPH interacts with YBX1, promotes YBX1-mediated activation of SNAIL1 translation, and upregulates SNAILI expression. Furthermore, IncRNA-AWPPH promotes YBX1-mediated activation of PIK3CA transcription, upregulates PIK3CA expression, and activates PI3K/AKT pathway. Depletion of YBX1 abolishes the effects of lncRNA-AWPPH on SNAILI and PIK3CA, and also the biological roles of lncRNA-AWPPH on HCC cells. In conclusion, this study identifies a novel IncRNA termed lncRNA-AWPPH which is highly expressed in HCC, indicates poor prognosis of HCC patients, and promotes HCC cell proliferation, migration, and in vivo tumor growth and metastasis via a novel regulatory mechanism of interacting with YBX1.
机译：已显示长期非编码RNA（Incrnas）在各种癌症中发挥重要作用。然而，Incrnas在肝细胞癌（HCC）中的临床意义和生物学作用仍然很大程度上是未知的。在本研究中，使用在线可用数据集和定量实时PCR，我们鉴定了一种称为LNCRNA-AWPPH的新型LNCRNA-AWPPH，其在HCC组织中高度表达。其上调与包封不完全，微血管入侵，高级TNM阶段和BCLC阶段相关。 Cox比例危害回归分析显示，高LNCRNA-AWPPH表达是无差的无复发和整体存活的独立预后因素。功能实验表明，LNCRNA-AWPPH的过度表达促进了HCC细胞增殖和体外肿瘤生长和转移的迁移。相反，LNCRNA-AWPPH的消耗对HCC具有相反的影响。机械地，IncRNA-AWPPH与YBX1相互作用，促进YBX1介导的Snail1翻译的激活，并提出鼻窦表达。此外，IncRNA-AWPPH促进YBX1介导的PIK3CA转录的激活，上调PIK3CA表达，并激活PI3K / AKT途径。 YBX1的耗竭消除了LNCRNA-AWPPH对SNAILI和PIK3CA的影响，以及LNCRNA-AWPPH对HCC细胞的生物学作用。总之，本研究确定了HCC高度表达的LNCRNA-AWPPH的新型IncRNA，表明HCC患者的预后差，并通过与互动的新调节机制提升HCC细胞增殖，迁移和转移。 YBX1。

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