The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate

Wood Matthew R; Bernal Ivan; Lalancette Roger A

首页> 外文期刊>Acta crystallographica. Section C, Structural chemistry. >The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate

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The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate

机译：危险的新型合成药物α-PVP，为水合氯化物盐α-吡咯烷基戊二酮盐酸盐0.786-水合物

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α-Pyrrolidinovalerophenone (α-PVP), a dangerous designer drug, is now being marketed around the world as a harmless `bath salt', when in reality it is a powerful β-ketone phenethylamine stimulant. A sample of the free base from a recent law-enforcement seizure was crystallized as the HCl salt [systematic name: 1-(1-oxo-1-phenylpentan-2-yl)pyrrolidin-1-ium chloride 0.786-hydrate], C15H22NO+·Cl?·0.786H2O. In the crystal structure, the propyl chain is nearly perpendicular to both the phenyl ring and the carbonyl group. The hydrogen-bonding scheme involves the quaternary N atom, the Cl? anion and the partially occupied (0.786) water molecule, forming centrosymmetric dimers.

机译：α-吡咯烷基戊二酮（α-PVP）是一种危险的设计药物，目前作为无害的“沐浴盐”在世界范围内销售，而实际上它是一种功能强大的β-酮苯乙胺兴奋剂。将最近一次执法缉获中的游离碱样品结晶为HCl盐[系统名称：1-（1-氧代-1-苯基戊烷-2-基）吡咯烷-1-氯化铵0.786水合物]，C15H22NO + ·Cl 2·0.786H 2O。在晶体结构中，丙基链几乎垂直于苯环和羰基。氢键方案涉及季氮原子Cl 2。阴离子和部分占据的（0.786）水分子，形成中心对称的二聚体。

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《Acta crystallographica. Section C, Structural chemistry.》 |2016年第1期|共4页
作者
Wood Matthew R; Bernal Ivan; Lalancette Roger A;
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正文语种 eng
中图分类晶体学;
关键词
bath salts; α-PVP; flakka; gravel; synthetic cathinones; crystal structure; α-pyrrolidinovalerophenone; designer drugs; β-ketone phenethylamine stimulant;

机译：浴盐;α-PVP;黄酮;砂砾;合成卡西酮;晶体结构;α-吡咯烷基戊二酮;指示剂;β-酮苯乙胺刺激剂;

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1. The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate [J] . Wood Matthew R, Bernal Ivan, Lalancette Roger A Acta crystallographica. Section C, Structural chemistry. . 2016,第1期

机译：危险的新型合成药物α-PVP，为水合氯化物盐α-吡咯烷基戊二酮盐酸盐0.786-水合物
2. Stereoselective effects of the second-generation synthetic cathinone -pyrrolidinopentiophenone (-PVP): assessments of conditioned taste avoidance in rats [J] . Nelson Katharine H., Lopez-Arnau Raul, Hempel Briana J., Psychopharmacology . 2019,第3期

机译：第二代合成胆醌 - 吡咯烷酮酮（-PVP）的立体选择作用：大鼠条件避免调节味道的评估
3. Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and alpha-pyrrolidinopentiophenone (alpha-PVP) in rhesus monkeys [J] . Psychopharmacology . 2019,第12期

机译：在恒河猴中自我施用3,4-甲基二氧基吡罗ROVOLONE（MDPV）和α-吡咯烷酮酮（Alpha-PVP）
4. Physical and Chemical Characterization of Hydrochloride Salts of Drug Substances by Dielectric and Calorimetric Analysis [C] . Manik Pavan Kumar Maheswaram Annual conference of the North American Thermal Analysis Society . 2012

机译：介电和量热法分析药物盐酸盐的理化性质
5. Characterizing the Neurochemical, Physiological and Behavioral Effects of the Synthetic Cathinone α-Pyrrolidinopentiophenone (α-PVP) [D] . Nelson, Katharine Hayley. 2021

机译：鉴于合成天然氨酸α-吡咯烷酮（α-PVP）的神经化学，生理和行为效果
6. Conditioned Taste Avoidance Conditioned Place Preference and Hyperthermia induced by the Second Generation ‘Bath Salt’ α-pyrrolidinopentiophenone (α-PVP) [O] . Katharine H. Nelson, Briana J. Hempel, Matthew M. Clasen, -1

机译：第二代沐浴盐α-吡咯烷基戊二酮（α-PVP）引起的有条件的口味避免有条件的位置偏爱和体温过高
7. Spectroscopic characterization and crystal structures of two cathinone derivatives: 1-(4-chlorophenyl)-2-(1-pyrrolidinyl)-pentan-1-one (4-chloro-α-PVP) sulfate and 1-(4-methylphenyl)-2-(dimethylamino)-propan-1-one (4-MDMC) hydrochloride salts, seized on illicit drug market [O] . Piotr Kuś, Joachim Kusz, Maria Książek, 2017

机译：两种显微氨酸衍生物的光谱表征和晶体结构：1-（4-氯苯基）-2-（1-吡咯烷基） - 硫酸盐和1-（4-甲基苯基） - -1-（4-甲基苯基） - 2-（二甲基氨基） - 盐酸盐盐盐盐，缉获非法药物市场
8. Storage of Low-Temperature Heat in Salt-Hydrate Melts: Calcium Chloride Hexahydrate [R] . Carlsson, B., Stymne, H., Wettermark, G. 1978

机译：盐水合物熔体中低温热量的储存：六水合氯化钙

The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate

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