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首页> 外文期刊>Biofabrication >Enhanced bioactivity of titanium-coated polyetheretherketone implants created by a high-temperature 3D printing process
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Enhanced bioactivity of titanium-coated polyetheretherketone implants created by a high-temperature 3D printing process

机译：通过高温3D印刷工艺产生的钛涂层聚醚醚酮植入物的增强生物活性

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摘要

Polyetheretherketone (PEEK), one of the potential alternatives to metallic materials for implants, necessarily involves high temperature process conditions to be three-dimensionally (3D) printed. We developed a 3D printing setup equipped with thermally stabilized modules of the printing nozzle and building chamber, by which the PEEK implants could be successfully manufactured. Under optimized printing conditions, the maximal mechanical strength of the 3D printed sample attained over 80% of the original bulk property of PEEK. To enhance the interfacial biocompatibility, the as-printed implants were postprocessed with titanium (Ti) sputtering. The Ti-coated surfaces were evaluated through characterization studies of x-ray diffraction spectra, microscopic topographies, and wetting properties. For the in vitro tests, preosteoblasts were cultured on the developed PEEK-Ti structures and evaluated in terms of cell adhesion, proliferation, and osteogenic differentiation. In addition, the bone regeneration capability of the PEEK-Ti implants was confirmed by animal experiments using a rabbit tibia defect model for a period of 12 weeks. In the overall in vitro and in vivo tests, we confirmed the superior bioactivities of the Ti-modified and 3D printed interface by comparisons between the samples of machined and printed samples with or without Ti coating. Taken together, the comprehensive manufacturing approaches that involve 3D printing and biocompatible postprocessing are expected to have universal applicability in a wide range of bone tissue engineering.
机译：聚醚醚酮（PEEK）是植入物金属材料的潜在替代品之一，必然涉及高温工艺条件，以三维（3D）印刷。我们开发了一种配备的3D打印设置，配备了印刷喷嘴和建筑物的热稳定模块，可以成功地制造PEEK植入物。在优化的印刷条件下，3D印刷样品的最大机械强度达到了PEEK原始散装性质的80％以上。为了增强界面生物相容性，用钛（Ti）溅射后涂抹植入物。通过对X射线衍射光谱，微观拓扑和润湿性能的表征研究来评估Ti涂覆的表面。对于体外试验，在发育的PEEK-TI结构上培养预卵细胞，并根据细胞粘附，增殖和骨质发生分化评估。此外，使用兔胫骨缺陷模型进行12周的兔胫骨缺陷模型，通过动物实验证实了PEEK-TI植入物的骨再生能力。在整体体外和体内测试中，我们通过在机加工和印刷样品的样品之间进行了比较，确认了Ti改性和3D印刷界面的优越性生物活体。在一起，涉及3D印刷和生物相容性后处理的综合制造方法预计将在各种骨组织工程中具有普遍适用性。

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  • 来源
    《Biofabrication》 |2019年第4期|共18页
  • 作者

    Jung Hyun-Do; Jang Tae-Sik; Lee Ji Eun; Park Seong Je; Son Yong; Park Suk-Hee;

  • 作者单位

    Korea Inst Ind Technol Res Inst Adv Mfg Technol Incheon 21999 South Korea;

    Korea Inst Ind Technol Res Inst Adv Mfg Technol Incheon 21999 South Korea;

    Korea Inst Ind Technol Digital Mfg Proc Grp 113-58 Seohaean Ro Siheung Si 15014 Gyeonggi Do South Korea;

    Korea Inst Ind Technol Digital Mfg Proc Grp 113-58 Seohaean Ro Siheung Si 15014 Gyeonggi Do South Korea;

    Korea Inst Ind Technol Digital Mfg Proc Grp 113-58 Seohaean Ro Siheung Si 15014 Gyeonggi Do South Korea;

    Korea Inst Ind Technol Digital Mfg Proc Grp 113-58 Seohaean Ro Siheung Si 15014 Gyeonggi Do South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

    3D printing; PEEK; Ti coating; biocompatibility; bone regeneration;

    机译：3D打印;PEEK;TI涂层;生物相容性;骨再生;

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