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首页> 外文期刊>Biochemical Genetics >Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells
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Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells

机译：ABHD6的基因表达，Endocannabinoid系统中的关键因素，可以通过人免疫细胞中的女性激素调节

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摘要

One of the main risk factors for the development of an autoimmune disease is to be a woman. Much attention has been given to the involvement of female hormones in their etiology and sexual bias, although the mechanisms behind this potentially strong contribution in disease susceptibility are poorly understood. ABHD6 gene was recently identified as a risk factor for system lupus erythematosus and the risk was correlated with overexpression of the gene. ABHD6 is an enzyme that degrades the 2-arachidonoylglycerol, an endocannabinoid with immunomodulatory effects. Thus its degradation could contribute to immune dysregulation and development of autoimmune reactions. Sex hormones, such as estrogens, are believed to regulate important genes in the endocannabinoid pathway. However, no study was available regarding the effect of these hormones in human immune cells. In this study, ABHD6 expression was evaluated by quantitative PCR in leukocytes from healthy male and females and in the presence of estrogen or progesterone (PG). A statistical increase in ABHD6 expression could be detected in women. In the presence of estrogen or PG, a statistical upregulation of ABHD6 was observed, and in a sex-dependent manner, as only female cells responded to stimulation. Our results suggest that female hormones can promote the overexpression of ABHD6 in immune cells. This can potentially contribute to a pro-inflammatory scenario and partially explain the association of this gene in the development of LES, a highly female-biased disease.
机译：用于开发自身免疫性疾病的主要风险因素之一是成为一个女人。虽然这种疾病易感性的潜在强烈贡献背后的机制理解，但对女性激素的参与感受很多。最近将ABHD6基因鉴定为系统狼疮红斑的危险因素，风险与基因的过表达相关。 ABHD6是一种酶，其降解了2- arachidonlglycerol，一种具有免疫调节效果的内胆蛋白。因此，其降解可能有助于免疫失调和自身免疫反应的发育。据信，雌激素，例如雌激素，以调节内突植物途径中的重要基因。然而，没有关于这些激素在人免疫细胞中的影响的研究。在该研究中，通过从健康雄性和女性的白细胞中的量化PCR评估ABHD6表达，并在雌激素或孕酮（PG）存在下。可以在女性中检测到ABHD6表达的统计增加。在雌激素或PG存在下，观察到ABHD6的统计上调，并且以性依赖性方式，因为只有雌性细胞响应刺激。我们的结果表明，女性激素可以促进免疫细胞中ABHD6的过度表达。这可能有助于促炎情景，部分解释该基因在LES的发展中的关联，这是一种高度雌性偏见的疾病。

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