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首页> 外文期刊>Biochemical Genetics >Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population
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Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population

机译：阿片类暴露与中国汉族人群中OPRM1启动子区的异常DNA甲基化有关

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摘要

The μ-opioid receptor (OPRM1) plays an important role in opiate addiction. The OPRM1 gene promoter showed hypermethylation in lymphocytes of opiate addicts as well as opioid medications users, while the methylation status displayed ethnic diversity. The purpose of the study was to investigate the methylation pattern of OPRM1 promoter in the Han Chinese population. We analyzed 22 CpG sites located in OPRM1 promoter in 186 former opiate addicts (94 males and 92 females) and 184 healthy controls (102 males and 82 females). The +?126 CpG site was significantly hypermethylated in the former heroin addicts compared with controls (13.67% versus 8.39%, $$P = 3.78 imes 10^{ - 9}$$ P = 3.78 × 10 - 9 , corrected for 36 tests). Six CpG sites were significantly associated with opioid exposure, including the most significant +126 CpG site (opiate addicts 13.57%, control 8.39%, $$P = 9.19 imes 10^{ - 12}$$ P = 9.19 × 10 - 12 , corrected for 36 tests), while the +23 GpG site was the only hypomethylated one in former opiate addicts compared with controls ( P ?=?0.0023 after Bonferroni correction). Our results supported that opioid exposure was associated with methylation status of OPRM1 promoter and showed ethnic dependence.
机译：μ-ApiOID受体（OPRM1）在鸦片成瘾中起着重要作用。 OPRM1基因启动子在阿片类药物的淋巴细胞和阿片类药物的淋巴细胞中显示出高甲基化，而甲基化状态呈现族裔多样性。该研究的目的是探讨汉族人群OPRM1启动子的甲基化模式。我们分析了位于OPRM1启动子的22个CPG网站，是186名前阿片上瘾者（94名男性和92名女性）和184名健康对照（102名男性和82名女性）。 +？126个CPG位点在前海洛因成瘾者中显着高甲基化与对照相比（13.67％对8.39％，$$ p = 3.78 times 10 ^ { - 9} $$ p = 3.78×10 - 9，校正36测试）。六个CPG位点与阿片类药物接触显着相关，包括最重要的+126个CPG网站（阿片成瘾者13.57％，控制8.39％，$$ P = 9.19 Times 10 ^ { - 12} $$ P = 9.19×10 - 12 ，校正36个测试），而+23 GPG位点是前阿片类成瘾者的唯一的甲甲基化，与对照相比（P？= 0.0023在Bonferroni校正之后）。我们的研究结果支持阿片类药物接触与OPRM1启动子的甲基化状态有关，并表现出种族依赖。

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  • 来源
    《Biochemical Genetics》 |2018年第5期|共8页
  • 作者

    Jiawei Xu; Teng Wang; Zhiyang Su; Xinyao Zhou; Yuqian Xiang; Lin He; Candong Li; Zhaoyang Yang; Xinzhi Zhao;

  • 作者单位

    Children’s Hospital and Institutes of Biomedical Sciences Fudan University;

    Children’s Hospital and Institutes of Biomedical Sciences Fudan University;

    Fujian University of Traditional Chinese Medicine;

    Children’s Hospital and Institutes of Biomedical Sciences Fudan University;

    Children’s Hospital and Institutes of Biomedical Sciences Fudan University;

    Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders;

    Fujian University of Traditional Chinese Medicine;

    Fujian University of Traditional Chinese Medicine;

    Children’s Hospital and Institutes of Biomedical Sciences Fudan University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    OPRM1; Opioid exposure; DNA methylation; Promoter; CpG sites;

    机译：OPRM1;阿片类药物暴露;DNA甲基化;启动子;CPG网站;

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