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首页> 外文期刊>Biochemical Genetics >Posttraumatic Stress Disorder Augments Plasma Triglycerides in TT Homozygotes of rs495225 at Growth Hormone Secretagogue Receptor Gene
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Posttraumatic Stress Disorder Augments Plasma Triglycerides in TT Homozygotes of rs495225 at Growth Hormone Secretagogue Receptor Gene

机译：Prostragumatic胁迫障碍在生长激素促蛋白质受体基因中增强了TT纯合蛋白质中的血浆甘油三酯

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摘要

Posttraumatic stress disorder (PTSD) and growth hormone secretagogue receptor (GHSR) were reported to be associated with plasma lipid and glucose levels. However, interplays of PTSD with GHSR on plasma lipid and glucose levels have not been explored yet. This study was to investigate the interplays of PTSD and GHSR rs495225 on plasma glucose and lipid profiles. A total of 709 high school students were recruited at 6months after the 2008 Wenchuan earthquake. Variants of GHSR rs495225 were identified by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing. The PTSD Checklist Civilian Version (PCL-C) was used to assess PTSD. There was no significant difference of PTSD prevalence between the TT homozygotes and the C allele carriers. However, the students with PTSD had significantly lower levels of glucose, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) than the students without PTSD in the C allele carriers of GHSR rs495225 after the adjustment for age, gender and body mass index (BMI), but higher levels of TG and TG/HDL-C in the TT homozygotes. Meanwhile, the TT homozygotes had lower levels of HDL-C than the C allele carriers in the students without PTSD, but higher levels of insulin and HOMA-IR in the subjects with PTSD. After the adjustment of age and gender, and additional adjustment for BMI, the results were not changed except the difference of insulin was only a tendency (p=0.054) after the additional adjustment for BMI. PTSD may augment TG levels and the related lipid ratio TG/HDL-C in the TT homozygotes of GHSR rs495225 but decrease the levels of glucose, insulin and HOMA-IR in the C allele carriers.
机译：据报道，宫外应激障碍（PTSD）和生长激素分泌糖酮受体（GHSR）与血浆脂质和葡萄糖水平相关。然而，尚未探讨PTSR对血浆脂质和血糖水平的GHSR的相互作用。本研究是调查PTSD和GHSR RS495225对血浆葡萄糖和脂质谱的相互作用。 2008年汶川地震后，共招募了709名高中生。通过聚合酶链反应限制片段长度多态性分析并通过DNA测序鉴定GHSR RS495225的变体。 PTSD清单平民（PCL-C）用于评估PTSD。在TT纯合蛋白和C等位基因载体之间没有显着差异患病率。然而，具有PTSD的学生患者含量显着降低了胰岛素抵抗（HOMA-IR）的葡萄糖，胰岛素和稳态模型评估，而不是在调整年龄，性别和体重指数的GHSR RS495225的C等位基因载体中的学生（BMI），但TT纯合子中的TG和TG / HDL-C水平较高。同时，TT Homozygotes的HDL-C水平低于学生中的C等位基因载体，而没有PTSD，但受试者的受试者中的胰岛素和HOMA-IR水平较高。在调整年龄和性别的调整后，除了BMI的额外调整后，除了胰岛素的差异仅在BMI的额外调节后患者差异（p = 0.054）而没有变化。 PTSD可以增强TG水平和GHSR RS495225的TT纯合的相关脂质比TG / HDL-C，但降低C等位基因载体中葡萄糖，胰岛素和HOMA-IR的水平。

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  • 来源
    《Biochemical Genetics》 |2019年第2期|共16页
  • 作者

    Su Mi; Si Yan Jun; Guo Qi Wei; Yang Mei; Chen Xu; Lin Jia; Fang Ding Zhi;

  • 作者单位

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

    Sichuan Univ Dept Biochem &

    Mol Biol West China Sch Basic Med Sci &

    Forens Med Chengdu 610041;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

    PTSD; GHSR; rs495225; Lipid; Insulin;

    机译：PTSD;GHSR;RS495225;脂质;胰岛素;

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