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首页> 外文期刊>Biochemical Genetics >Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China
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Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China

机译：中国南方山羊群中醛脱氢酶2基因多态性与脑梗死的关系

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Genetic factors play an important role in determining the susceptibility to ischemic stroke. Herein, we examined the association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with cerebral infarction. Patients with cerebral infarction (n = 963) and healthy controls (n = 921) were included. Genotyping was performed using gene chip platform analysis, and Sanger sequencing was used to confirm ALDH2 genotypes. The risk prediction of ALDH2 polymorphisms for cerebral infarction was examined under three genetic modes of inheritance. For males, ALDH2*2/*2 genotype was a significant risk factor for cerebral infarction in the co-dominant model (age-, smoking-, and drinking-adjusted OR 1.514, 95% CI 1.005-2.282, p = 0.047) and the recessive model (age-, smoking-, and drinking-adjusted OR 1.601, 95% CI 1.078-2.379, p = 0.020). However, for females, ALDH2*2/*2 genotype was a protective factor for cerebral infarction in the co-dominant model (age-, smoking-, and drinking-adjusted OR 0.450 95% CI 0.215-0.941, p = 0.034) and the recessive model (age-, smoking-, and drinking-adjusted OR 0.440, 95% CI 0.214-0.903, p = 0.025). Further, logistic regression analysis revealed that age, smoking, hypertension, hyperlipidemia, and hypercholesterolemia were significant risks for the presence of cerebral infarction. In conclusion, these findings support an association of ALDH2 gene polymorphisms with ischemic stroke in a Chinese Hakka population. In particular, homozygote ALDH2*2/*2 may be a risk factor for cerebral infarction in males, but contribute to reduced risk for cerebral infarction in females.
机译：遗传因素在确定对缺血性卒中的易感性方面发挥着重要作用。在此，我们研究了醛脱氢酶2（ALDH2）基因多态性与脑梗塞的结合。包括脑梗死患者（n = 963）和健康对照（n = 921）。使用基因芯片平台分析进行基因分型，使用Sanger测序来确认AldH2基因型。在三种遗传模式下检查了脑梗死的ALDH2多态性的风险预测。对于雄性，Aldh2 * 2 / * 2基因型是合作模型中脑梗死的显着危险因素（年龄，吸烟和饮用调整或1.514,95％CI 1.005-2.282，P = 0.047）和隐性模型（年龄，吸烟和饮用调整或1.601,95％CI 1.078-2.379，P = 0.020）。然而，对于女性，Aldh2 * 2 / * 2基因型是共同主导模型中脑梗死的保护因子（年龄，吸烟和饮用调整或0.450 95％CI 0.215-0.941，P = 0.034）和隐性模型（年龄，吸烟和饮用调整或0.440,95％CI 0.214-0.903，P = 0.025）。此外，Logistic回归分析显示，年龄，吸烟，高血压，高脂血症和高胆固醇血症是存在脑梗死存在的显着风险。总之，这些发现支持Aldh2基因多态性与缺血性中风中的缺血性脑卒中关联。特别是，Homozygote Aldh2 * 2 / * 2可能是脑梗死中患者脑梗死的危险因素，但有助于减少女性脑梗死的风险。

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