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首页> 外文期刊>Biological chemistry >The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3
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The regulation, localization, and functions of oxygen-sensing prolyl hydroxylase PHD3

机译：氧传感脯氨酰羟化酶PHD3的调节，定位和功能

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摘要

The prolyl 4-hydroxylase domain protein 3 (PHD3) belongs to 2-oxoglutarate and iron-dependent dioxygenases. Together with the two closest paralogues, PHD1 and PHD2, these enzymes have been identified as cellular oxygen sensors that can mark the hypoxia-inducible factor a (HIF-alpha) for von Hippel-Lindau protein-mediated proteasomal destruction. Although having overlapping functions with PHD1 and PHD2, PHD3 markedly differs from the two isoforms. PHD3 shows a different expression pattern and subcellular localization as well as activity under low oxygen tension. Moreover, it has the widest range of non-HIF targets underlying its diverse functions. The functions of PHD3 differ depending on the cell type and also partially on the microenvironmental conditions it is expressed at. Under normoxia, PHD3 has been shown to be proapoptotic, but under hypoxia, it can have cell survival or proliferation-supporting functions. Here we discuss the regulation, targets, and functions of PHD3.
机译：脯氨酰4-羟化酶结构域蛋白3（PHD3）属于2-氧缺乏酸盐和依赖性二氧基团。 与两个最近的寄生喹，PHD1和PHD2一起，这些酶已被鉴定为细胞氧传感器，其可以标记Von Hippel-Lindau蛋白介导的蛋白酶体破坏的缺氧诱导因子A（HIF-α）。 尽管具有PHD1和PHD2的重叠功能，但PHD3与两种同种型显着不同。 PHD3显示出不同的表达模式和亚细胞定位以及低氧张力下的活性。 此外，它具有其不同功能的最广泛的非HIF靶标。 PHD3的功能根据细胞类型而不同，并且部分在其上表达的微环境条件下。 根据常氧，PHD3已被证明是proapoftotic，但在缺氧下，它可以具有细胞存活或增殖支持功能。 在这里，我们讨论了PHD3的监管，目标和功能。

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