The progress in corneal translational medicine

Hancox Zoe; Keshel Saeed Heidari; Yousaf Safiyya; Saelnasab Morvarid; Shahbazi Mohammad-Ali; Sefat Farshid

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The progress in corneal translational medicine

机译：角膜翻译医学的进展

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Cornea tissue is in high demand by tissue donation centres globally, and thus tissue engineering cornea, which is the main topic of corneal translational medicine, can serve as a limitless alternative to a donated human cornea tissue. Tissue engineering aims to produce solutions to the challenges associated with conventional cornea tissue, including transplantation and use of human amniotic membrane (HAM), which have issues with storage and immune rejection in patients. Accordingly, by carefully selecting biomaterials and fabrication methods to produce these therapeutic tissues, the demand for cornea tissue can be met, with an improved healing outcome for recipients with less associated harmful risks. In this review paper, we aim to present the recent advancements in the research and clinical applications of cornea tissue, applications including biomaterial selection, fabrication methods, scaffold structure, cellular response to these scaffolds, and future advancements of these techniques.

机译：角膜组织对全球组织捐赠中心的需求很大，因此组织工程角膜是角膜翻译医学的主要话题，可以作为捐赠的人角膜组织的无限替代品。组织工程旨在产生与常规角膜组织相关的挑战的解决方案，包括移植和使用人羊膜（HAM），患者储存和免疫排斥有问题。因此，通过仔细选择生物材料和制造方法以产生这些治疗组织，可以满足对角膜组织的需求，具有改善的愈合结果，适用于具有较少相关的有害风险的受体。在本文中，我们的目标是展示角膜组织的研究和临床应用的最新进展，包括生物材料选择，制造方法，支架结构，对这些支架的细胞反应以及这些技术的未来进步。

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《Biomaterials Science》 |2020年第23期|共36页
作者
Hancox Zoe; Keshel Saeed Heidari; Yousaf Safiyya; Saelnasab Morvarid; Shahbazi Mohammad-Ali; Sefat Farshid;
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作者单位

Univ Bradford Sch Engn Dept Biomed &

Elect Engn Bradford W Yorkshire England;

Shahid Beheshti Univ Med Sci Sch Adv Technol Med Dept Tissue Engn &

Appl Cell Sci Tehran Iran;

Univ Bradford Sch Engn Dept Biomed &

Elect Engn Bradford W Yorkshire England;

Ferdowsi Univ Mashhad Fac Sci Dept Biol Mashhad Razavi Khorasan Iran;

Univ Helsinki Fac Pharm Div Pharmaceut Chem &

Technol Drug Res Program FI-00014 Helsinki Finland;

Univ Bradford Sch Engn Dept Biomed &

Elect Engn Bradford W Yorkshire England;

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正文语种 eng
中图分类分子生物学;
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1. The progress in corneal translational medicine [J] . Hancox Zoe, Keshel Saeed Heidari, Yousaf Safiyya, Biomaterials Science . 2020,第23期

机译：角膜翻译医学的进展
2. Challenges, progress, and new directions in stem cell therapies: a new section launched in Clinical and Translational Medicine [J] . Mariusz Z. Ratajczak, Xiangdong Wang Clinical and Translational Medicine . 2015,第1期

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3. The First International Optogenetic Therapies for Vision Symposium: Translational medicine in progress [J] . ZarbinM.A. JAMA ophthalmology . 2014,第9期

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4. Implementation of a Master's in Translational Medicine (MTM) Program at The City College of New York (Work in Progress) [C] . Jeffrey Stock Garanich, Lola A. Brown American Society for Engineering Education Annual Conference and Exposition . 2018

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5. Progress towards the human chromatome: Global and targeted analysis of chromatin proteins and their post-translational modifications using mass spectrometry-based proteomics. [D] . Plazas-Mayorca, Mariana De Jesus. 2010

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6. Progress of Cancer Nanotechnology as Diagnostics Therapeutics and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges [O] . Sultan Alshehri, Syed Sarim Imam, Md. Rizwanullah, 2021

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7. The progress in corneal translational medicine [O] . Zoe Hancox, Saeed Heidari Keshel, Safiyya Yousaf, 2020

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The progress in corneal translational medicine

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