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Hydrogen peroxide regulates angiogenesis-related factors in tumor cells

机译：过氧化氢调节肿瘤细胞中的血管生成相关因素

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2 O 2 is a ROS with an important role in cell signaling, but how H 2 O 2 regulates tumor angiogenesis is still poorly understood. We have xenografted tumor cells with altered levels of H 2 O 2 by catalase overexpression into zebrafish embryos to study redox-induced tumor neovascularization. We found that vascular recruitment and invasion were impaired if catalase was overexpressed. In addition, the overexpression of catalase altered the transcriptional levels of several angiogenesis-related factors in tumor cells, including TIMP-3 and THBS1. These two anti-angiogenic factors were found to be H 2 O 2 -regulated by two different mechanisms: TIMP-3 expression in a cell-autonomous manner; and, THBS1 expression that was non-cell-autonomous. Our work shows that intracellular H 2 O 2 regulates the expression of angiogenic factors and the formation of a vessel network. Understanding the molecular mechanisms that govern this multifunctional effect of H 2 O 2 on tumor angiogenesis could be important for the development of more efficient anti-angiogenic therapies.
机译：2 o 2是具有在细胞信号传导中具有重要作用的RO，但H 2 O 2如何调节肿瘤血管生成仍然不知识。通过过氧化氢酶过滤成斑马鱼胚胎具有改变的H 2 O 2水平的异种移植肿瘤细胞，以研究氧化还原诱导的肿瘤新生血管化。我们发现如果过滤酶过表达，则发现血管招生和侵袭受损。此外，过滤酶的过表达改变了肿瘤细胞中几种血管生成相关因子的转录水平，包括TIMP-3和THBS1。发现这两种抗血管生成因子是通过两种不同机制的H 2 O 2：以细胞自主方式的TIMP-3表达;而且，THBS1表达是非细胞自主的。我们的工作表明，细胞内H 2 O 2调节血管生成因子的表达和血管网络的形成。了解治理H 2 O 2对肿瘤血管生成的这种多功能效应的分子机制对于开发更有效的抗血管生成疗法可能是重要的。

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