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首页> 外文期刊>Biochemistry and Cell Biology >Regulation of the insulin–Akt signaling pathway and glycolysis during dehydration stress in the African clawed frog Xenopus laevis
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Regulation of the insulin–Akt signaling pathway and glycolysis during dehydration stress in the African clawed frog Xenopus laevis

机译：在非洲爪青蛙Xenopus Laevis中脱水应力期间胰岛素-AKT信号通路和糖酵解的调节

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Xenopus laevis during the dehydration stress induced state of estivation. We show that in the brain and heart of X. laevis , dehydration reduces the phosphorylation of the insulin growth factor-1 receptor (IGF-1R), and this is followed by similar reductions in the phosphorylation of the Akt and mechanistic target of rapamycin (mTOR) kinase. Interestingly, phosphorylation levels of IGF-1R and mTOR were not affected in the kidney, and phosphorylation levels of P70S6K and the ribosomal S6 protein were elevated during dehydration stress. Animals under estivation are also susceptible to periods of hypoxia, suggesting that glycolysis may also be affected. We observed that protein levels of many glycolytic enzymes remained unchanged during dehydration; however, the hypoxia response factor-1 alpha (HIF-1α) protein was elevated by greater than twofold in the heart during dehydration. Overall, we provide evidence that shows that the insulin signaling pathway in X. laevis is regulated in a tissue-specific manner during dehydration stress and suggests an important role for this signaling cascade in mediating the estivation response.
机译：Xenopus Laevis在脱水应力诱导的培养状态。我们表明，在X. Laevis的大脑和心脏中，脱水减少了胰岛素生长因子-1受体（IGF-1R）的磷酸化，然后在雷帕霉素的Akt和机械靶标中的磷酸化类似的降低（ mtor）激酶。有趣的是，IGF-1R和MTOR的磷酸化水平不受肾脏的影响，并且在脱水应力期间升高P70S6K和核糖体S6蛋白的磷酸化水平。在培养的动物也易于缺氧时期，表明糖酵解也可能受到影响。我们观察到许多糖酵解酶的蛋白质水平在脱水期间保持不变;然而，在脱水期间，缺氧响应因子-1α（HIF-1α）蛋白在心脏中升高大于双重。总体而言，我们提供了证据表明，在脱水应力期间以组织特异性方式调节X. Laevis中的胰岛素信号传导途径，并表明该信号级联在介导股价反应中的重要作用。

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