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首页> 外文期刊>Biochemistry and Cell Biology >Portal vein ligation alters coding and noncoding gene expression in rat livers
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Portal vein ligation alters coding and noncoding gene expression in rat livers

机译：门静脉结扎改变大鼠肝脏的编码和非编码基因表达

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摘要

Portal vein occlusion increases the resectability of initially unresectable liver cancer by inducing hypertrophy in non-occluded liver lobes. However, the mechanisms of how portal vein occlusion induces hepatic hypertrophy remain unclear. A cDNA microarray was used to identify the gene expression signatures of ligated (LLLs) and nonligated liver lobes (NLLLs) at different time points after portal vein ligation (PVL). The results of a bioinformatics analysis revealed that LLLs and NLLLs displayed different gene expression profiles. Moreover, the expression levels of both coding and noncoding RNA were different between LLLs and NLLLs at different time points after PVL. A series test of cluster analysis revealed that the No. 22 and No. 5 expression patterns, which showed altered expression at 24 h and maintained this altered expression over the following 14 days, had the lowest P values and the highest number of differentially expressed genes in both the LLLs and NLLLs. The results of a GO analysis showed the activation of hypoxia pathways in LLLs and the activation of cell proliferation and cell-cycle pathways in NLLLs, suggesting the involvement of these pathways in PVL-induced hepatic hypertrophy and regeneration. These results provide insight into the molecular mechanisms underlying hepatic hypertrophy and regeneration induced by portal vein occlusion, and they identify potential targeting pathways that can promote the clinical application of PVL in liver cancer therapy.
机译：门静脉闭塞通过在非闭塞肝裂片中诱导肥大来增加最初不可切除的肝癌的可折伤性。然而，门静脉闭塞如何诱导肝肥大的机制仍然不清楚。使用cDNA微阵列在门静脉连接（PVL）之后在不同时间点鉴定连接（LILLS）和非触发的肝叶（NILLS）的基因表达签名。生物信息学分析的结果显示LLLS和NILLS显示不同的基因表达谱。此外，PVL之后在不同时间点的LLLS和Nlll之间的表达水平与LLLS和NILL之间的表达水平不同。簇分析的串联试验表明，在24小时内显示出改变的表达的第22和第5种表达模式并在接下来的14天内保持这种改变的表达，具有最低的P值和最多的差异表达基因数量在llls和nllls中。 Go分析的结果显示LLLS中缺氧途径的激活和NILLS中细胞增殖和细胞循环途径的激活，表明这些途径在PVL诱导的肝肥大和再生中的参与。这些结果提供了对由门静脉闭塞诱导的肝肥大和再生的分子机制的洞察力，它们识别潜在的靶向途径，可促进PVL在肝癌疗法中的临床应用。

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  • 来源
    《Biochemistry and Cell Biology》 |2018年第1期|共10页
  • 作者

    Bin Li; Yan Zhu; Lei Xie; Shuyang Hu; Shupeng Liu; Xiaoqing Jiang;

  • 作者单位

    Biliary Tract Surgery Department I Eastern Hepatobiliary Surgery Hospital Secondary Military;

    Department of Pathology Changhai Hospital Secondary Military Medical University Shanghai China.;

    Biliary Tract Surgery Department I Eastern Hepatobiliary Surgery Hospital Secondary Military;

    Biliary Tract Surgery Department I Eastern Hepatobiliary Surgery Hospital Secondary Military;

    Clinical Research Center Changhai Hospital Secondary Military Medical University Shanghai China.;

    Biliary Tract Surgery Department I Eastern Hepatobiliary Surgery Hospital Secondary Military;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    portal vein ligation; microarray; rat model; liver regeneration;

    机译：门静脉结扎;微阵列;大鼠模型;肝再生;

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