Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility

Kyzar Evan J.; Zhang Huaibo; Pandey Subhash C.

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Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility

机译：青少年酒精曝光表现出杏仁氨基弧增强子RNA表达以赋予成人焦虑易感性

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BACKGROUND: Adolescent intermittent ethanol (AIE) exposure is an emerging risk factor for adult psychopathology, such as anxiety disorders. Enhancer RNAs (eRNAs) are short noncoding RNAs transcribed from enhancer regions that regulate synaptic plasticity-associated gene expression, including Arc, but their role in AIE-induced susceptibility to anxiety in adulthood is unknown.

机译：背景：青少年间歇性乙醇（AIE）暴露是成人精神病理学的新出现危险因素，如焦虑症。增强剂RNA（ERNAS）是从增强子区域转录的短的非致rNA，其调节突触可塑性相关的基因表达，包括弧，但它们在AIE诱导的AIE诱导对成年焦虑的敏感性的作用是未知的。

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来源
《Biological psychiatry》 |2019年第11期|共11页
作者
Kyzar Evan J.; Zhang Huaibo; Pandey Subhash C.;
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作者单位

Univ Illinois Dept Psychiat Ctr Alcohol Res Epigenet 1601 West Taylor St M-C 912 Chicago IL;

Univ Illinois Dept Psychiat Ctr Alcohol Res Epigenet 1601 West Taylor St M-C 912 Chicago IL;

Univ Illinois Dept Psychiat Ctr Alcohol Res Epigenet 1601 West Taylor St M-C 912 Chicago IL;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Adolescent alcohol; Amygdala; Anxiety; Arc; Enhancer RNA; epigenetic;

机译：青春期间;杏仁肉;焦虑;弧;增强剂RNA;表观遗传;

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1. Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility [J] . Kyzar Evan J., Zhang Huaibo, Pandey Subhash C. Biological psychiatry . 2019,第11期

机译：青少年酒精曝光表现出杏仁氨基弧增强子RNA表达以赋予成人焦虑易感性
2. Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking [J] . Sakharkar Amul J., Kyzar Evan J., Gavin David P., Neuropharmacology . 2019,第期

机译：青春期酒精暴露后改变杏仁醛甲基化机制有助于成人焦虑和酒精饮用
3. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala [J] . Huaibo Zhang, Evan J. Kyzar, John Peyton Bohnsack, Scientific reports. . 2018,第1期

机译：青少年酒精暴露表观遗传调控成年杏仁核中的CREB信号传导
4. NOCTURNAL MELATONIN SUPPRESSION BY ADOLESCENTS AND ADULTS FOR DIFFERENT LEVELS, SPECTRA, AND DURATIONS OF LIGHT EXPOSURE [C] . Figueiro M.G., Nagare R., Rea M.S. Session of the CIE . 2019

机译：夜间褪黑激素抑制青少年和成人不同级别，光谱和光曝光持续时间
5. The Impact of Gestational Day 12 Moderate Prenatal Alcohol Exposure on Anxiogenic Behavior and the Expression of Amygdala GABAA-alpha1 in Adolescent Males [D] . Rouzer, Siara K. 2017

机译：妊娠第12天中度产前酒精暴露对青春期男性焦虑行为和杏仁核GABAA-alpha1表达的影响
6. MicroRNA-137 Drives Epigenetic Reprogramming in the Adult Amygdala and Behavioral Changes after Adolescent Alcohol Exposure [O] . Evan J. Kyzar, John Peyton Bohnsack, Huaibo Zhang, 2019

机译：MicroRNA-137驱动成人杏仁核中的表观遗传重编程和青少年酒精暴露后的行为变化
7. Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility [O] . Evan J. Kyzar, Huaibo Zhang, Subhash C. Pandey 2019

机译：青少年酒精曝光表现出杏仁氨基弧增强子RNA表达以赋予成人焦虑易感性

Adolescent Alcohol Exposure Epigenetically Suppresses Amygdala Arc Enhancer RNA Expression to Confer Adult Anxiety Susceptibility

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