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首页> 外文期刊>Biological research for nursing >Perceived Stress, Its Physiological Correlates, and Quality of Life in Patients With Irritable Bowel Syndrome
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Perceived Stress, Its Physiological Correlates, and Quality of Life in Patients With Irritable Bowel Syndrome

机译：肠易激综合征患者的应激，其生理相关性和生活质量

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Irritable bowel syndrome (IBS) is a chronic, common disorder of the gastrointestinal tract associated with high psychological comorbidity and diminished quality of life. Patients with IBS display a heightened sensitivity to stress, although the literature is inconsistent as to whether they have a dysregulated stress response. The purpose of the present investigation, a substudy of a larger research effort, was to examine physiological correlates of perceived stress in patients with IBS (cortisol and adrenocorticotropic hormone) and to explore associations between perceived stress and quality of life. A total of 101 participants (35 with IBS [predominant subtypes IBS-constipation and IBS-diarrhea] and 66 healthy controls [HCs]) completed self-report inventories regarding perceived stress and quality of life, and fasting peripheral blood was drawn. Participants with IBS did not differ from the HC in demographic or physiological measures but did differ in psychological measures, reporting significantly higher levels of perceived stress and lower levels of quality of life. Perceived stress and quality of life were not significantly associated in IBS participants. However, differential findings of the stress response were found within IBS participants by sex, race, and subtype. These findings illustrate the heterogeneity of the IBS patient population, underscore the necessity of evaluating larger sample sizes and increasing the diversity of such samples to include males and ethnic minorities, and demonstrate the importance of taking an individualized approach to evaluation and treatment in the IBS patient population.
机译：肠易激综合征（IBS）是慢性，胃肠道常见疾病，与高性能合并症和衰减的生活质量下降相关。患有IBS的患者显示对压力的高度敏感性，尽管文献与它们是否具有疑虑的应激反应不一致。目前调查的目的是替代更大的研究努力，是为了研究IBS（皮质醇和肾上腺皮质激素）患者的感知压力的生理相关性，并探讨感知压力和生活质量之间的关联。共有101名参与者（35人[主要亚型IBS - 腹泻和IBS-DiaRRRHEA]和66例健康对照[HCS]）完成了关于感知压力和生命质量的自我报告库存，并且抽取了空腹外周血。 IBS的参与者没有与人群或生理措施中的HC不同，但在心理上的措施中有所不同，报告显着更高的感知压力和较低的生活质量。在IBS参与者中，感知的压力和生活质量没有显着相关。然而，通过性，种族和亚型，在IBS参与者中发现了压力反应的差异结果。这些发现说明了IBS患者群体的异质性，强调了评估更大样本大小的必要性，并增加这些样品的多样性以包括雄性和少数群体，并证明在IBS患者中采取个性化方法的重要性。人口。

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