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A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness

机译：慢性疾病疲劳生物学机制的系统综述

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Fatigue, a commonly reported symptom, is defined as an overwhelming, debilitating, and sustained sense of exhaustion that decreases the ability to function and carry out daily activities. To date, cancer researchers have been in the forefront in investigating the possible biological mechanisms of fatigue, identifying inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and activation of the autonomic nervous system. The purpose of this systematic review is to describe fatigue and what is known about the biological mechanisms described in cancer in five chronic, noninfectious illnesses: heart failure, multiple sclerosis, chronic kidney disease, rheumatoid arthritis, and chronic obstructive pulmonary disease. We searched PubMed and EMBASE using fatigue as a major Medical subject headings (MeSH) heading with each individual disease added as a search term followed by each biological mechanism. We included only primary research articles published in English between 1996 and 2016 describing studies conducted in adult humans. We identified 26 relevant articles. While there is some evidence that the biological mechanisms causing fatigue in cancer are also associated with fatigue in other chronic illnesses, more research is needed to explore inflammation, the HPA axis, and the autonomic nervous system, and other mechanisms in relation to fatigue in a variety of chronic illnesses.
机译：疲劳是一个常见的症状，被定义为压倒性，衰弱和持续的疲惫感，这降低了运作和开展日常活动的能力。迄今为止，癌症研究人员已经处于研究疲劳的可能生物学机制，鉴定炎症，丘脑垂体 - 肾上腺（HPA）轴的激活和激活自主神经系统的活性的最前沿。该系统审查的目的是描述疲劳，以及癌症中描述的五种慢性，无排血疾病：心力衰竭，多发性硬化症，慢性肾病，类风湿性关节炎和慢性阻塞性肺病中所描述的患者所知的疲劳和讨论。我们使用疲劳作为主要的医学主题标题（网格）搜索PubMed并嵌入，每个疾病添加为每个生物机制。我们仅包括1996年至2016年间英语发布的主要研究文章，描述了成人人类进行的研究。我们确定了26条相关文章。虽然有一些证据表明，在其他慢性疾病中导致癌症疲劳的生物机制也与疲劳有关，但需要更多的研究来探索炎症，HPA轴和自主神经系统，以及与a的疲劳有关的其他机制各种慢性疾病。

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