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首页> 外文期刊>Cytokine >Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis.
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Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis.

机译：白介素7是一种有效的髓鞘特异性T细胞共刺激剂，可增强实验性自身免疫性脑脊髓炎的过继转移。

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摘要

Interleukin 7 (IL-7), originally described as a B cell growth factor, has recently been found to play a critical role in T and B lymphocyte development and function. This study evaluated the effects of IL-7 on myelin specific T cells. IL-7 strongly enhanced proliferation of proteolipid protein (PLP) 139-151 specific T cells in association with elevated secretion of the T cell growth factor IL-2. Co-stimulation with IL-7 preferentially increased the levels of pro-inflammatory cytokines secreted by PLP 139-151 specific T cells and adoptive transfer of these cells into naive recipients induced a profound enhancement of experimental autoimmune encephalomyelitis, an animal model for the human disease multiple sclerosis. These results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders.
机译：白细胞介素7（IL-7），最初被描述为B细胞生长因子，最近发现在T和B淋巴细胞的发育和功能中起关键作用。这项研究评估了IL-7对髓磷脂特异性T细胞的作用。 IL-7与T细胞生长因子IL-2分泌增加有关，可大大增强蛋白脂质蛋白（PLP）139-151特异性T细胞的增殖。与IL-7共同刺激可优先增加PLP 139-151特异性T细胞分泌的促炎性细胞因子的水平，并将这些细胞过继转移至幼稚受体中，从而极大地增强了实验性自身免疫性脑脊髓炎（一种人类疾病的动物模型）多发性硬化症。这些结果表明，IL-7可能是一个关键的共刺激因子，可增强炎症性T细胞的胸腺外扩张，并可能在许多炎症性自身免疫性疾病的发病机理中发挥重要作用。

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