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首页> 外文期刊>Biopreservation and biobanking >Determination of Dielectric Properties of Cryoprotective Agent Solutions with a Resonant Cavity for the Electromagnetic Rewarming in Cryopreservation
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Determination of Dielectric Properties of Cryoprotective Agent Solutions with a Resonant Cavity for the Electromagnetic Rewarming in Cryopreservation

机译：用谐振腔测定冷冻保护剂溶液的介电性质，用于冷冻保存中的电磁复再生

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摘要

In the rewarming process during cryopreservation, preventing ice recrystallization and thermal stress is important, especially for large tissues and organs. Uniform and rapid heating is essential in ameliorating the problem and maintaining the viability of cryopreserved biological samples. Currently, the most promising method is heating by application of electromagnetic (EM) waves, the effectiveness of which is dependent on the dielectric properties (DP) of the cryopreserved materials. In this work, the cavity perturbation method was adopted to measure the DP of cryoprotectant solutions. Based on the values of DP, the cryoprotectant solutions most amenable to EM heating can be identified. A system composed of a rectangular resonant cavity, a network analyzer, and a fiber optic temperature meter was implemented for the measurement. The DP of three cryoprotectant solutions during cooling to -80 degrees C were measured and presented. The data can be used to optimize the rewarming process with the numerical method. The results show that a cryoprotectant solution consisting of 41% (w/v) dimethyl sulfoxide and 6% (w/v) polyvinylpyrrolidone has the highest dielectric loss for EM rewarming among the tested solutions. In addition, the developed DP measurement system could not only improve the EM heating in cryopreservation but also benefit hyperthermia or other therapies associated with EM waves.
机译：在冷冻保存期间的复再生过程中，防止冰重结晶和热应力是重要的，特别是对于大型组织和器官。均匀和快速加热对于改善问题并保持冷冻保存的生物样品的活力至关重要。目前，最有希望的方法是通过施加电磁（EM）波来加热，其有效性取决于冷冻保存材料的介电性质（DP）。在这项工作中，采用腔扰动方法测量冷冻保护剂溶液的DP。基于DP的值，可以识别最适合EM加热的冷冻保护液。为测量实施了由矩形谐振腔，网络分析仪和光纤温度计组成的系统。测量并呈现在冷却至-80℃的三种冷冻保护剂溶液的DP。数据可用于利用数值方法优化复活过程。结果表明，由41％（w / v）二甲基亚砜和6％（w / v）聚乙烯吡咯烷酮组成的冷冻保护剂溶液具有最高的测试溶液中的介电损耗。此外，开发的DP测量系统不仅可以改善冷冻保存中的EM加热，还可以损害热疗或与EM波相关的其他疗法。

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