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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Evaluation of the hepatoprotective, anti-inflammatory, antinociceptive and antiepileptic activities of Chrysanthemum trifurcatum
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Evaluation of the hepatoprotective, anti-inflammatory, antinociceptive and antiepileptic activities of Chrysanthemum trifurcatum

机译：评价菊花三呋喃抑制的肝保护剂，抗炎，抗闭合性和抗癫痫症

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摘要

Chrysanthemum trifurcatum is common to Mediterranean countries and widely-used in traditional medicine. Due to the scarcity of data about the pharmacological properties of C. trifurcatum, this present study was designed to determine the effects of C. trifurcatumethanolic extract (CEE) for its anti-nociceptive, anti-epileptic, anti-inflammatory, and hepatoprotective activities in mice and rat models. We demonstrate that CEE contains alkaloids, carbohydrates, and flavonoids, and in a dose-dependent (300 and 500 mg/kg) manner exhibited significant reductions in paracetamol (PCM; 500 mg/kg)-induced increased serum AST, ALT and ALP levels, similar to as seen by silymarin (25 mg/kg). Additionally, CEE (300 mg/kg) elicited inhibition in acetic acid-induced abdominal writhes, delayed latency time to paw's licking in hot plate tests, exerted an anti-convulsant effect by prolonging the onset of clonic and tonic convulsions, and reduced pentylenetetrazole (PTZ; 80 mg/kg)-induced mortality. Moreover, CEE (500 mg/kg) exhibited a prominent reduction in carrageenan-induced paw edema. These studies indicate that CEE possesses profound central and peripheral analgesic, anti-convulsant, anti-inflammatory, and hepatoprotective activities.
机译：Chrysanthemum Trifurcatum对地中海国家共同，广泛用于传统医学。由于关于C. Trifurcatum的药理学特性的数据稀缺，本研究旨在确定C. TrifurcaTumethanolic提取物（CEE）对其抗伤害，抗癫痫，抗炎和肝脏保护活性的影响小鼠和大鼠模型。我们证明CEE含有生物碱，碳水化合物和黄酮类化合物，并且在剂量依赖性（300和500mg / kg）的方式上表现出扑热氨基酚（PCM; 500mg / kg）的显着减少 - 诱导的血清AST，ALT和ALP水平增加，类似于Silymarin（25mg / kg）所见。此外，CEE（300mg / kg）引发抑制在乙酸诱导的腹部缠绕中，延迟延迟时间以爪子在热板试验中舔的延迟时间，通过延长克隆和滋补痉挛的发作来施加抗惊厥作用，并降低五苯乙烯释放唑（ PTZ; 80 mg / kg）引起的死亡率。此外，CEE（500mg / kg）在角叉菜胶诱导的爪子水肿中表现出突出的减少。这些研究表明，CEE具有深刻的中枢和外周镇痛，抗惊厥药，抗炎和肝保护活性。

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