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首页> 外文期刊>Cytokine >Plasma and urine levels of resistin and adiponectin in chronic kidney disease.
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Plasma and urine levels of resistin and adiponectin in chronic kidney disease.

机译：慢性肾脏病患者血浆和尿液中抵抗素和脂联素的水平。

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BACKGROUND: Subjects with chronic kidney disease (CKD) have an increased risk of developing coronary atherosclerosis. Adipocyte hormones, resistin and adiponectin are implicated in insulin resistance and atherosclerosis. However, few studies in the literature address the role of adipocyte hormones in CKD. The aim of this study was to compare the levels of resistin, adiponectin and other inflammatory markers in subjects with CKD with those of the control subjects. MATERIALS AND METHODS: In a cross-sectional study, we measured basal metabolic panel, fasting lipid panel and levels of glucose, resistin, adiponectin, insulin, C-reactive protein (CRP) and TNF-alpha in 43 subjects with CKD compared with those of 34 control subjects. We also measured the resistin and adiponectin levels in urine samples (16). RESULTS: Subjects with CKD have increased insulin levels and insulin resistance index (IRI). Compared with controls, subjects with CKD had increased levels of resistin (5.12+/-3.2 vs.7.5+/-5.9; p<0.05), CRP (1.7+/-2.2 vs. 5.97+/-6.0; p<0.0005), and TNF-alpha (3.4+/-2.0 vs. 5.2+/-3.5; p<0.005). Resistin levels correlate with CRP and TNF-alpha, even with BMI as a covariate. Although 60% of subjects with CKD have CAD, e plasma levels of adiponectin were not decreased in subjects with CKD compared with controls (17.02+/-9.8 vs. 16.40+/-9.0 with p value 0.78). Urinary adiponectin levels correlate inversely with GFR (r=-0.4; p<0.05) and plasma adiponectin levels (r=0.9; p<0.0001). CONCLUSIONS: Subjects with CKD had normal levels of plasma adiponectin despite the adverse metabolic environment for CAD. In addition, this study demonstrates the relationship between resistin and TNF-alpha in subjects with CKD and suggests that resistin may play a role in the sub-clinical inflammation associated with CKD, suggesting that adiponectin clearance may be decreased as shown by the inverse correlation of urinary adiponectin with GFR.
机译：背景：患有慢性肾脏疾病（CKD）的受试者发生冠状动脉粥样硬化的风险增加。脂肪细胞激素，抵抗素和脂联素与胰岛素抵抗和动脉粥样硬化有关。然而，文献中很少有研究探讨脂肪细胞激素在CKD中的作用。这项研究的目的是比较CKD受试者与对照受试者的抵抗素，脂联素和其他炎症标记物的水平。材料与方法：在一项横断面研究中，我们测量了43名CKD受试者的基础代谢指标，空腹血脂指标以及葡萄糖，抵抗素，脂联素，胰岛素，C反应蛋白（CRP）和TNF-α的水平， 34个控制对象。我们还测量了尿液样本中的抵抗素和脂联素水平（16）。结果：CKD患者的胰岛素水平和胰岛素抵抗指数（IRI）升高。与对照组相比，CKD患者的抵抗素水平升高（5.12 +/- 3.2 vs.7.5 +/- 5.9; p <0.05），CRP（1.7 +/- 2.2 vs. 5.97 +/- 6.0; p <0.0005）和TNF-α（3.4 +/- 2.0对5.2 +/- 3.5; p <0.005）。抵抗素水平与CRP和TNF-α相关，甚至与BMI为协变量。尽管60％的CKD受试者患有CAD，但与对照组相比，CKD受试者的血浆脂联素水平并未降低（17.02 +/- 9.8与16.40 +/- 9.0，p值0.78）。尿脂联素水平与GFR（r = -0.4; p <0.05）和血浆脂联素水平（r = 0.9; p <0.0001）成反比。结论：尽管CAD的代谢环境不利，但CKD患者的血浆脂联素水平正常。此外，这项研究证明了CKD患者抵抗素与TNF-α之间的关系，并表明抵抗素可能在与CKD有关的亚临床炎症中起作用，这表明脂联素清除率可能降低，如反式相关。尿脂联素与GFR。

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