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首页> 外文期刊>Cytokine >Constitutive expression of CXCL14 in healthy human and murine epithelial tissues.
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Constitutive expression of CXCL14 in healthy human and murine epithelial tissues.

机译：CXCL14在健康人和鼠上皮组织中的组成型表达。

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摘要

CXCL14 (BRAK) is an ill-described chemokine with unknown receptor selectivity. The human chemokine is constitutively expressed in epithelial tissues and is selective for dendritic cell precursors, indicating a possible function in the maintenance of epithelial DCs. Several studies have addressed the question of human CXCL14 expression in cancerous tissues; however, distribution in healthy tissues and, in particular, the cellular origin of this chemokine has not been thoroughly investigated. The expression pattern of murine CXCL14 is largely unknown. In agreement with the human chemokine, we demonstrated ubiquitous and constitutive expression of murine CXCL14 in various tissues, foremost in those of epithelial origin such as the skin and the gastrointestinal tract. In addition, we did not find any CXCL14 in lymphoid tissues. Interestingly and in contrast to humans, murine CXCL14 was strongly expressed in the lung. In the skin, CXCL14 was produced by keratinocytes and dermal macrophages in both mice and humans, whereas CXCL14-expressing mast cells could only be found in the human dermis. Therefore, despite the remarkable structural homology and the broad similarity in the tissue distribution of human and murine CXCL14, distinct differences point to diverse, species-specific needs for CXCL14 in epithelial immunity.
机译：CXCL14（BRAK）是一种未知的趋化因子，其受体选择性未知。人趋化因子在上皮组织中组成性表达，并且对树突状细胞前体具有选择性，表明在维持上皮DC中可能的功能。一些研究已经解决了人类CXCL14在癌组织中表达的问题。但是，尚未对健康组织中的分布，特别是该趋化因子的细胞起源进行彻底研究。鼠CXCL14的表达模式很大程度上未知。与人趋化因子一致，我们证明了鼠CXCL14在各种组织中的普遍存在和组成型表达，尤其是在上皮来源的组织（如皮肤和胃肠道）中。此外，我们在淋巴组织中未发现任何CXCL14。有趣的是，与人类相反，鼠CXCL14在肺中强烈表达。在皮肤中，CXCL14由小鼠和人类的角质形成细胞和真皮巨噬细胞产生，而表达CXCL14的肥大细胞仅在人真皮中发现。因此，尽管在人和鼠CXCL14的组织结构上具有显着的结构同源性和广泛的相似性，但明显的差异表明CXCL14在上皮免疫方面具有多种，物种特异性的需求。

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