...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Placental growth factor blunts uterine artery responses to angiotensin II
【24h】

Placental growth factor blunts uterine artery responses to angiotensin II

机译：胎盘生长因子与血管紧张素II的子宫内动脉反应钝化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell-shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor receptor-1 (sFlt-1) on responses of human uterine arteries (UA) to Ang II. Design Experimental. Setting Baylor College of Medicine and Texas Children's Hospital-Pavilion for Women. Sample Uterine arteries samples (n = 14) were obtained from normotensive women undergoing caesarean hysterectomy at >= 32 weeks. Methods Uterine arteries rings were incubated with (1) Krebs solution; (2) PlGF at 1.45, 14.5, and 500 pg/ml; (3) sFlt-1 at 2 ng/ml; and (4) a combination of sFlt-1, and PlGF. Dose-contraction responses to Ang II were determined in UA rings incubated in the above-mentioned conditions. Responses were also measured in presence of L-NAME or inhibitors of endothelium-derived hyperpolarising factor: apamine and charybdotoxin. The t-test was used for comparisons. Main outcome measure Changes in vascular reactivity of UA rings. Results PlGF blunted (P = 0.03) and sFlt-1 increased (P <0.01) the UA maximum responses to Ang II. A combination of sFlt-1 and PlGF blunted UA responses to Ang II (P < 0.05). l-NAME, apamine, and charybdotoxin reversed the relaxation effects of PlGF on UA responses to Ang II (P < 0.05). Conclusions PlGF contributes to the blunted vascular response to Angiotensin II during normotensive pregnancies and sFlt-1 appears to attenuate this effect. PlGF and sFlt-1 may contribute to the regulation of vascular tone during pregnancy by altering the vascular response to Angiotensin II.
机译：胎盘生长因子（PLGF）母体血清浓度的目的变化及对血管紧张素II（Ang II）血管内输注的血管反应遵循妊娠期间的钟形曲线图案。该研究评估了PLGF和可溶性血管内皮生长因子受体-1（SFLT-1）对人子宫动脉（UA）至Ang II反应的影响。设计实验。设置贝勒医学院和德克萨斯儿童医院为女性馆。样品子宫动脉样品（n = 14）是从在> = 32周的正常剖腹症子宫切除术的正常血浆中获得。方法将子宫子弹环与（1）克雷布溶液一起温育; （2）PLGF在1.45,14.5和500 pg / ml; （3）SFLT-1在2ng / ml处; （4）SFLT-1和PLGF的组合。在上述条件下温育的UA环中测定对Ang II的剂量收缩响应。还在内皮衍生的超极化因子的L-名称或抑制剂存在下测量反应：Apamine和Charybdotoxin。 T检验用于比较。 uA环血管反应性的主要结果测量变化。结果PLGF钝化（P = 0.03）和SFLT-1增加（P <0.01）UA对ANG II的最大响应。 SFLT-1和PLGF的组合钝化UA对Ang II的反应（P <0.05）。 L-NAME，APAMINE和CHARYBDOTOXIN反转PLGF对ANG II的响应的松弛作用（P <0.05）。结论PLGF在正常妊娠期间对血管紧张素II的血管反应呈现出钝化的血管反应，SFLT-1似乎衰减了这种效果。通过改变对血管紧张素II的血管反应，PLGF和SFLT-1可能有助于妊娠期血管间调的调节。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号