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首页> 外文期刊>Cytokine >Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.
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Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.

机译：新墨西哥州患有和不患有乳腺癌的女性细胞因子基因和血清细胞因子水平的多态性。

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Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched pairs) for 25 single nucleotide polymorphisms (SNPs) in cytokine genes. We measured corresponding serum cytokine levels as well. Five cytokines (IL-1beta, IL-5, TNF-alpha, IL-6 and IL-2) were significantly associated with disease and based on their serum levels, concentrations were higher in the cases than in the controls. Disease odds ratios corresponding to one standard deviation change in log-transformed concentrations of these cytokines were 18.87, 4.10, 3.61, 3.27 and 2.52. Three most statistically significant SNPs were rs2069705, located in the promoter region of the interferon gamma gene (INF-gamma); rs2243248, in the promoter of IL-4 (rs2243248); and rs1800925, in the promoter of the IL-13 gene. Increased serum cytokine levels at diagnosis are indicative for immunological alterations and possibly related to genetic susceptibility markers as well. These findings might guide us to understand the presence of SNPs in cytokine genes and serum concentrations among breast cancer patients and potentially in other cancers.
机译：在墨西哥新西班牙裔妇女中，与非西班牙裔白人妇女相比，发现乳腺癌的年龄更高。很少研究的一个中心因素是关键细胞因子的作用。我们对细胞因子基因中的25个单核苷酸多态性（SNPs）进行了乳腺癌事件及其年龄，性别和吸烟匹配对照（N = 40个匹配对）的基因分型。我们还测量了相应的血清细胞因子水平。五种细胞因子（IL-1β，IL-5，TNF-α，IL-6和IL-2）与疾病显着相关，根据其血清水平，病例中的浓度高于对照组。对应于这些细胞因子的对数转化浓度的一个标准偏差变化的疾病优势比为18.87、4.10、3.61、3.27和2.52。位于干扰素γ基因（INF-γ）启动子区域的三个统计学上最显着的SNP为rs2069705; rs2243248，在IL-4（rs2243248）的启动子中;和rs1800925，位于IL-13基因的启动子中。诊断时血清细胞因子水平升高表明免疫学改变，也可能与遗传易感性标志物有关。这些发现可能指导我们了解乳腺癌患者以及其他潜在癌症患者的细胞因子基因和血清浓度中是否存在SNP。

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