A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

Penning LC; Denecker G; Vercammen D; Declercq W; Schipper RG; Vandenabeele P

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A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

机译：钾在人和啮齿动物肿瘤细胞系中由TNF诱导的细胞凋亡和基因诱导中的作用。

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Rat/mouse T cell hybridoma-derived PC60 R55/R75 cells were used as a model to study the role of intracellular potassium in TNF-induced apoptosis and gene induction. A reduction of intracellular potassium with nigericin or valinomycin (ionophores), or ouabain (Na(+)/K(+)-ATPase inhibitor) sensitized PC60 R55/R75 cells to TNF-induced apoptosis. TNF-induced GM-CSF release in PC60 R55/R75 cells was enhanced by nigericin or ouabain. Similar results were obtained with human cervix carcinoma cells HeLaH21 exposed to TNF. These results suggest a role for intracellular potassium in TNF-induced apoptosis and gene induction. Copyright 2000 Academic Press.

机译：使用大鼠/小鼠T细胞杂交瘤细胞衍生的PC60 R55 / R75细胞作为模型，研究细胞内钾在TNF诱导的细胞凋亡和基因诱导中的作用。用尼日利亚霉素或缬氨霉素（离子载体）或哇巴因（Na（+）/ K（+）-ATPase抑制剂）减少细胞内钾，可使PC60 R55 / R75细胞对TNF诱导的细胞凋亡敏感。尼日利亚或哇巴因可增强PC60 R55 / R75细胞中TNF诱导的GM-CSF释放。用暴露于TNF的人宫颈癌细胞HeLaH21获得了相似的结果。这些结果表明细胞内钾在TNF诱导的细胞凋亡和基因诱导中的作用。版权所有2000学术出版社。

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《Cytokine》 |2000年第6期|共4页
作者
Penning LC; Denecker G; Vercammen D; Declercq W; Schipper RG; Vandenabeele P;
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正文语种 eng
中图分类细胞生物学;
关键词
Apoptosis; Gene Expression Regulation; Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; 脱噬作用; 基因表达调控; 肿瘤; 粒细胞巨噬细胞集落刺激因子; 钾; 肿瘤坏死因子;

机译：Apoptosis;Gene Expression Regulation;Neoplastic;Granulocyte-Macrophage Colony-Stimulating Factor;脱噬作用;基因表达调控;肿瘤;粒细胞巨噬细胞集落刺激因子;钾;肿瘤坏死因子;

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专利

1. A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. [J] . Penning LC, Denecker G, Vercammen D, Cytokine . 2000,第6期

机译：钾在人和啮齿动物肿瘤细胞系中由TNF诱导的细胞凋亡和基因诱导中的作用。
2. Natural occurring sesquiterpene lactone Spiciformin induces apoptosis and activation of mitogen-activated protein kinase pathway on human tumour cell lines. [J] . Rubio Sanchez Sara, Estevez Francisco, Saavedra Saavedra Ester, Basic & clinical pharmacology & toxicology. . 2019,第S4期

机译：天然发生的倍二萜内酯蛋白质Spicificin诱导人肿瘤细胞系诱导偶氮活性蛋白激酶途径的凋亡和激活。
3. Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines. [J] . Gerelchuluun A, Hong Z, Sun L, International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations . 2011,第1期

机译：200 MeV质子和10 MV X射线在人肿瘤细胞系中诱导原位DNA双链断裂和凋亡。
4. Apoptosis induced by tumour necrosis factor alpha in human hepatoma cell lines [C] . S. ROUSSET, A. BRINGUIER, B. LARDEUX, Falk Symposium . 2000

机译：肿瘤坏死因子α在人肝细胞系中诱导的凋亡
5. Role of Bcl-2 family proteins in apoptosis of human hepatoma cell lines. [D] . Luo, Dan. 1998

机译：Bcl-2家族蛋白在人肝癌细胞系凋亡中的作用。
6. Expression of p53 Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. [O] . H. Burger, K. Nooter, A. W. Boersma, 1998

机译：p53Bcl-2和Bax在顺铂诱导的睾丸生殖细胞肿瘤细胞系凋亡中的表达。
7. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets [O] . Lara Bellini, Mélanie Campana, Claude Rouch, 2018

机译：ELOVL2 / DOCOSEXANENOC酸轴在糖尿病毒素诱导的啮齿动物β细胞和人胰岛中凋亡的保护作用

A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

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