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首页> 外文期刊>Cytokine >Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice.
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Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice.

机译：断奶导致小鼠中分泌特定细胞因子的肠道淋巴细胞数量增加。

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摘要

Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer's patches and lamina propria of small intestine in mice by enzyme linked immunosorbent spot (ELISPOT) during 1 month after weaning. We have found a high percentage of spontaneous Th(1)as well as Th(2)cytokine-secreting lymphocytes in both populations, Peyer's patches and lamina propria. An increase in the number of the lymphocytes secreting most of the studied cytokines, at 1 and 2 weeks after weaning, was also observed. These results suggest that the increase in the number of cytokine secreting lymphocytes may be one of the potential mechanisms involved in the development of the intestinal immune system at weaning. Copyright 2000 Academic Press.
机译：肠道免疫与全身免疫在几个方面有所不同，因此经常单独进行研究。在这项工作中，我们分析了自发分泌细胞因子IL-2，IL-4，IL-5，IL-6，IL-10，干扰素γ（IFN-γ）和肿瘤坏死因子（TNF-α）的单核细胞的频率），在断奶后1个月内，通过酶联免疫吸附剂斑点（ELISPOT）在小鼠的Peyer斑块和小肠固有层中。我们在两个种群，派伊尔斑块和固有层中都发现了高百分比的自发Th（1）以及Th（2）分泌细胞因子的淋巴细胞。还观察到在断奶后1和2周，分泌大多数研究的细胞因子的淋巴细胞数量增加。这些结果表明，分泌细胞因子的淋巴细胞数量的增加可能是断奶时肠道免疫系统发育的潜在机制之一。版权所有2000学术出版社。

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