Diminished cytokines gene expression in lymphoid organs of healthy aged rats.

Pachowka M; Makula J; Korczak Kowalska G

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Diminished cytokines gene expression in lymphoid organs of healthy aged rats.

机译：健康老年大鼠淋巴器官中细胞因子基因表达的减少。

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Immunuosenescence-related dysregulation of cytokine production is not fully understood and the roles of cytokines in organ aging have been insufficiently studied. This work aimed to compare the expression of interleukin-2 (IL-2), IL-4, IL-6, interferon-gamma (IFNgamma), and transforming growth factor-beta (TGFbeta) in lymphoid organs of young (3 months; n = 10), adult (1 year; n = 10), and aged (2 years; n = 7) rats under healthy, steady-state conditions. Cytokine mRNA levels were determined with TaqMan real-time PCR. In the spleen, all cytokine expression gradually declined with age (for representative cytokine IL-2 averages dCt in spleens of 3 months, 1 year and 2 years rats were 13,645, 13,19 and 15,470, respectively). In lymph nodes, all cytokines except TGF-beta showed markedly upregulated expression in adult compared to young rats, but all were expressed at very low levels in aged rats. In bone marrow, adult animals showed enhanced IL-2, IFNgamma, and TGFbeta expression, but similar IL-4 and IL-6 expression, compared to young rats. Bone marrow of aged rats showed very low expression of all the measured cytokines. Our results demonstrated that changes occurred unevenly with aging in different immune system compartments.

机译：尚不完全了解与细胞衰老相关的免疫衰老相关的失调，并且尚未充分研究细胞因子在器官衰老中的作用。这项工作旨在比较年轻（3个月）淋巴器官中白细胞介素2（IL-2），IL-4，IL-6，干扰素-γ（IFNγ）和转化生长因子-β（TGFbeta）的表达。 n = 10），成年（1岁; n = 10）和成年（2岁; n = 7）大鼠处于健康，稳定状态。用TaqMan实时PCR测定细胞因子mRNA水平。在脾脏中，所有细胞因子的表达均随着年龄的增长而逐渐下降（对于3个月，1年和2年大的大鼠脾脏中代表性细胞因子IL-2的平均dCt分别为13,645、13,19和15,470）。与年轻大鼠相比，在淋巴结中，除TGF-β以外的所有其他细胞因子均在成年大鼠中表达明显上调，但在成年大鼠中均以非常低的水平表达。与年轻大鼠相比，成年动物的骨髓中IL-2，IFNγ和TGFbeta表达增强，但IL-4和IL-6表达相似。老年大鼠的骨髓显示所有测量的细胞因子的表达都非常低。我们的结果表明，变化随不同免疫系统区室的老化而发生不均匀。

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《Cytokine》 |2011年第1期|共5页
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Pachowka M; Makula J; Korczak Kowalska G;
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1. Diminished cytokines gene expression in lymphoid organs of healthy aged rats. [J] . Pachowka M, Makula J, Korczak Kowalska G Cytokine . 2011,第1期

机译：健康老年大鼠淋巴器官中细胞因子基因表达的减少。
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机译：实验性变应性脑脊髓炎小鼠淋巴器官和外周血单个核细胞中细胞因子基因表达的模式。
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机译：猪生殖和呼吸综合征病毒感染的猪的淋巴器官中促炎细胞因子的差异表达。
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机译：有和没有稳态过氧化氢的低氧对单核细胞衍生巨噬细胞细胞因子基因和蛋白质表达的影响
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机译：正常和猿猴免疫缺陷病毒（SIV）感染的猕猴的淋巴组织中细胞因子基因表达的模式。
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机译：移植物抗宿主病中皮肤和淋巴器官中细胞因子基因的表达。
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机译：移植物抗宿主病中皮肤和淋巴器官中细胞因子基因的表达。
8. Hemorrhagic Shock-Induced Vascular Hyporeactivity in the Rat: Relationship to Gene Expression of Nitric Oxide Synthase, Endothelin-1, and Select Cytokines in Corresponding Organs. [R] . Liu, L., Dubick, M. A. 2005

机译：出血性休克诱导的大鼠血管低反应性：与相应器官中一氧化氮合酶，内皮素-1和选择细胞因子的基因表达的关系。

Diminished cytokines gene expression in lymphoid organs of healthy aged rats.

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