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首页> 外文期刊>BJU international >Urinary nerve growth factor level could be a biomarker in the differential diagnosis of mixed urinary incontinence in women.
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Urinary nerve growth factor level could be a biomarker in the differential diagnosis of mixed urinary incontinence in women.

机译：尿道神经生长因子水平可能是妇女混合尿失禁的鉴别诊断中的生物标志物。

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OBJECTIVES: To measure urinary nerve growth factor (NGF) levels in women with stress urinary incontinence (SUI) and overactive bladder symptoms (OAB) and to assess whether urinary NGF levels can be a biomarker of detrusor overactivity (DO) in women with mixed urinary incontinence. PATIENTS, SUBJECTS AND METHODS: Urinary NGF levels were measured in 38 women with urodynamic SUI (USI) with OAB, in 26 with urodynamic DO but no SUI, in 21 with persistent USI after anti-incontinence surgery, in 15 with de novo DO, and in 31 normal control subjects. All participants had a video-urodynamic study for the differential diagnosis of the underlying causes of UI. Urinary NGF levels were measured using an enzyme-linked immunosorbent assay and were compared among all subgroups, and corrected using urinary creatinine (Cr) levels. RESULTS: The mean (sem) urinary NGF/Cr levels were low both in controls, at 0.06 (0.004) and in women with pure USI, at 0.056 (0.037) (P = 0.108). The NGF/Cr levels were significantly higher in women with mixed USI and DO, at 1.00 (0.244), than in controls (P < 0.001) and those with pure USI (P = 0.006), but were similar to the levels in women with pure DO, at 0.58 (0.17) (P = 0.058). The NGF/Cr levels were undetectable in women with persistent USI but were significantly higher in those with de novo DO, at 2.39 (0.90), after anti-incontinence surgery than in controls and those with USI. A urinary NGF/Cr level of >0.05 was found in 9% of women with USI, 77% with DO, 81% with mixed USI and DO, and 80% with de novo DO. CONCLUSION: The urinary NGF level could be a potential biomarker of DO in women with mixed UI.
机译：目的：测量患有压力尿失禁（SUI）和过度活跃的膀胱症状（OAB）的女性中泌尿神经生长因子（NGF）水平，并评估尿NGF水平是否可以是尿液中妇女的戒烟过度患者（DO）的生物标志物失禁。患者，受试者和方法：在38名患有尿液中苏（USI）的女性中测量尿NGF水平，其中26例尿液动力学，但在21例抗尿失禁手术后21例，在缺尿病外，在诺夫（De Novo）中，在31个正常对照科目中。所有参与者都有一个视频尿动力学研究，用于uI的潜在原因的差异诊断。使用酶联免疫吸附试验测量尿NGF水平，并在所有亚组中进行比较，并使用尿肌酐（Cr）水平校正。结果：对照组（SEM）尿性NGF / Cr水平低0.06（0.004）和纯USI的女性，0.056（0.037）（P = 0.108）。含有混合USI的妇女的NGF / Cr水平显着高，在1.00（0.244），比对照（P <0.001）和纯USI的妇女（P = 0.006），但与妇女的水平相似纯洁，0.58（0.17）（p = 0.058）。 NGF / Cr水平在持久性USI的女性中不可检测，但在Novo患者中显着提高，抗失禁手术比对照组和USI的妇女。在9％的USI中发现了尿NGF / Cr水平> 0.05，其中77％，含量为77％，混合USI和Do Novo Do of Do Novo。结论：泌尿NGF水平可能是混合UI妇女的潜在生物标志物。

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