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首页> 外文期刊>BJU international >Biodegradable braided poly(lactic-co-glycolic acid) urethral stent combined with dutasteride in the treatment of acute urinary retention due to benign prostatic enlargement: a pilot study.
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Biodegradable braided poly(lactic-co-glycolic acid) urethral stent combined with dutasteride in the treatment of acute urinary retention due to benign prostatic enlargement: a pilot study.

机译：可生物降解的编织聚（乳酸 - 共乙醇酸）尿道支架联合荷兰甾醇治疗急性尿潴留因良性前列腺增大：试验研究。

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OBJECTIVE: To evaluate, in a pilot study, the efficacy and safety of combining a braided poly(lactic-co-glycolic acid) (PLGA, a copolymer of l-lactide and glycolide) urethral stent and dutasteride in the treatment of acute urinary retention (AUR) due to benign prostatic enlargement (BPE). PATIENTS AND METHODS: Ten men with AUR due to BPE were treated as outpatients. A biodegradable braided PLGA urethral stent was inserted into the prostatic urethra, using a specially designed insertion device under visual control. Dutasteride treatment was started and the patients were followed up for 3 months after insertion of the stents. RESULTS: In all patients the stents were placed successfully with the new insertion device. All men were able to void after inserting the stent. At 1 month five patients voided freely with a low residual urine volume (<150 mL), two voided but had a high residual urine volume and a suprapubic catheter was placed, and three needed a suprapubic or an indwelling catheter before 1 month,due to AUR or comorbidities. At 3 months five patients were voiding with no problems. CONCLUSIONS: We have developed a new and effective insertion device for biodegradable braided prostatic stents. The new braided-pattern stent overcomes the earlier problems of migration and sudden breakage into large particles associated with biodegradable spiral stents. However, the mechanical properties of the new stent need to be improved and tested in a longer follow-up. We consider that this new biodegradable braided-pattern urethral stent could provide a new option in the future treatment of AUR.
机译：目的：在试验研究中评估，在试验研究中，将编织聚（乳酸 - 乙醇酸）（PLGA，L-丙交酯和乙酰胺的PLGGA，共聚物）尿道支架和携带术治疗急性尿潴留的疗效和安全性（AUR）由于良性前列腺增大（BPE）。患者和方法：由于BPE引起的10名患者被视为门诊病人。使用特殊设计的插入装置在视觉控制下，可生物降解的编织PLGA尿道支架插入前列腺尿道中。加入杜藤酰胺治疗，患者在插入支架后3个月。结果：在所有患者中，支架用新的插入装置成功置于。在插入支架后，所有男性都能够空洞。在1个月的五个患者用低残留的尿量（<150mL）可自由排出，两个空隙但具有高残留的尿量，放置了一种静脉导管，并且在1个月之前需要三个素质或留置导管，因此Aur或合并症。在3个月内，第五名患者没有任何问题。结论：我们开发了一种用于可生物降解的编织前列面支架的新且有效的插入装置。新的编织模式支架克服了与可生物降解螺旋支架相关的大颗粒的迁移和突然破裂的前面的问题。然而，在更长的随访中需要改进和测试新支架的机械性能。我们认为这种新的可生物降解的编织模式尿道支架可以在未来的AUR治疗中提供新的选择。

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