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首页> 外文期刊>Cytokine >Hyaluronectin secretion by monocytes: downregulation by IL-4 and IL-13, upregulation by IL-10.
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Hyaluronectin secretion by monocytes: downregulation by IL-4 and IL-13, upregulation by IL-10.

机译：单核细胞分泌透明质素：IL-4和IL-13下调，IL-10上调。

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Hyaluronectin (HN) is a component of the extracellular matrix of connective tissue and is particularly associated with tumour inflammatory and connective stroma reaction, where it co-localizes with hyaluronic acid (HA). The HN/HA ratio has been suggested to be involved in tumour aggressivity and in the atherosclerosis process. IL-10 has also been described in atherosclerotic lesions and in cancer. HN production was therefore investigated in vitro in peripheral blood monocyte cell (PBMC) cultures, with and without bacterial lipolysaccharide (LPS) or interleukins (ILs) in the medium. HN was characterized in monocytic cell cytoplasm and in culture supernatants. Anti-IL-10 antibody suppressed the LPS-stimulating effect on HN production. HN synthesis rate was greatly increased in IL-10-activated cultures while IL-4 and IL-13, two other anti-inflammatory ILs, decreased HN release. In the presence of IL-10, the IL-4 or Il-13 inhibitory effect on HN synthesis was reversed. The results support the view that intratumoral release of IL-10 by monocytes may induce local production of HN. In conjunction with the known ability of HN to bind to HA, which is a cell migration and tumour invasion facilitating factor, and to inhibit HA-induced angiogenesis, our findings suggest that HN may modulate the effect of HA on atherosclerosis, angiogenesis and cancer development. Copyright 1999 Academic Press.
机译：透明质酸（HN）是结缔组织细胞外基质的组成部分，尤其与肿瘤炎症和结缔基质反应有关，在透明质酸中与透明质酸（HA）共定位。已经表明，HN / HA比值与肿瘤的侵袭性和动脉粥样硬化过程有关。 IL-10也已经在动脉粥样硬化病变和癌症中被描述。因此，在体外血液单核细胞（PBMC）培养中研究了HN的产生，在培养基中有无细菌脂多糖（LPS）或白介素（ILs）。 HN在单核细胞细胞质和培养上清液中表征。抗IL-10抗体抑制了LPS对HN产生的刺激作用。在激活IL-10的培养物中，HN的合成速率大大提高，而另外两种抗炎性ILs IL-4和IL-13则降低了HN的释放。在IL-10存在下，IL-4或II-13对HN合成的抑制作用被逆转。结果支持这样的观点，即单核细胞在肿瘤内释放IL-10可能诱导HN的局部产生。结合已知的HN与HA结合的能力，HA是细胞迁移和肿瘤侵袭的促进因子，并抑制HA诱导的血管生成，我们的发现表明HN可能调节HA对动脉粥样硬化，血管生成和癌症发展的作用。版权所有1999，学术出版社。

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