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首页> 外文期刊>Cytokine >Presence of interleukin 10 in the serum and blister fluid of patients with pemphigus vulgaris and pemphigoid.
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Presence of interleukin 10 in the serum and blister fluid of patients with pemphigus vulgaris and pemphigoid.

机译：寻常型天疱疮和类天疱疮患者的血清和水疱液中存在白介素10。

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摘要

Interleukin 10 (IL-10) is an immunoregulatory cytokine produced by T lymphocytes and macrophages. Recently, it has been suggested that IL-10 may be involved in the pathogenesis of various inflammatory and autoimmune diseases. Using an ELISA we investigated the presence of IL-10 in the serum and blister fluid of pemphigus vulgaris (PV) patients with active disease and those in prolonged clinical remission compared with normal controls. Sera from patients with bullous pemphigoid (BP), ocular cicatricial pemphigoid (OCP), oral pemphigoid (OP) and blister fluid from five patients with BP were also studied. Increased levels of IL-10 were detected in the sera of 87.5% of patients with active PV and were statistically significant (P=0.0003) when compared with levels in normal human serum. Lower levels of IL-10 were detected in 12.5% PV patients in remission and were statistically significant (P=0.0001) when compared with levels in patients with active disease. Levels of IL-10 were detected in sera of 4.6% (1 of 24) of the normal controls. The levels of IL-10 were approximately four times higher in blister fluids than levels in the serum in the same PV patients. This difference was highly statistically significant (P=0.0008). A correlation was observed between serum levels of IL-10 and titres of pemphigus autoantibodies and with disease severity. Elevated level of IL-10 was detected in the blister fluid from five BP patients. Levels of IL-10 in the sera of patients with BP, OCP and OP were not significantly increased. These preliminary data suggest that IL-10 in concert with other cytokines may play an important role in the pathogenesis of PV and BP. Copyright 2000 Academic Press.
机译：白介素10（IL-10）是由T淋巴细胞和巨噬细胞产生的免疫调节细胞因子。最近，已经提出IL-10可能参与各种炎性和自身免疫疾病的发病机理。使用ELISA，我们调查了患有活动性疾病的天疱疮（PV）患者以及与正常对照组相比临床缓解期较长的患者的血清和水疱液中IL-10的存在情况。还研究了来自5名BP患者的大疱性天疱疮（BP），眼瘢痕性天疱疮（OCP），口服天疱疮（OP）和起泡液患者的血清。在87.5％的活动性PV患者血清中检测到IL-10水平升高，与正常人血清中的水平相比，具有统计学意义（P = 0.0003）。与活动性疾病患者相比，缓解的12.5％PV患者中IL-10水平较低，并且具有统计学意义（P = 0.0001）。在正常对照组的4.6％（24个中的1个）血清中检测到IL-10水平。在相同的PV患者中，泡罩液中的IL-10水平约为血清中水平的四倍。这种差异具有高度的统计学意义（P = 0.0008）。血清IL-10水平与天疱疮自身抗体滴度之间以及疾病严重程度之间存在相关性。在五名BP患者的水疱液中检测到IL-10水平升高。 BP，OCP和OP患者血清中的IL-10水平没有明显增加。这些初步数据表明，IL-10与其他细胞因子协同作用可能在PV和BP的发病机理中起重要作用。版权所有2000学术出版社。

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