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首页> 外文期刊>Cytokine >Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease.
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Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease.

机译：牙周健康和疾病中单核细胞趋化蛋白1的血清水平。

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OBJECTIVES: Initial research has reported high levels of monocyte chemoattractant protein-1 (MCP-1) in gingival crevicular fluid (GCF) of periodontitis patients. Present study has been carried out to assess its concentration in serum and to find its association with periodontal health and disease. DESIGN: 60 subjects were divided into three groups (n=20) based on gingival index (GI), probing pocket depth (PPD) and clinical attachment loss (CAL): healthy (group I), gingivitis (group II) and chronic periodontitis (group III). A fourth group (group IV) consisted of 20 subjects from group III, 6-8 weeks after treatment [i.e. scaling and root planing (SRP)]. Serum samples obtained from each patient were quantified for MCP-1 using enzyme-linked immunosorbent assay (ELISA). RESULTS: The mean MCP-1 concentration in serum was found to be the highest in group III i.e. 465.80 pg/ml and lowest in group I i.e. 155.20 pg/ml. For group II (251.60 pg/ml) and group IV (263.20 pg/ml) the mean MCP-1 concentrations were found to lie in between the concentrations obtained in group I and III. CONCLUSIONS: Serum MCP-1 concentration was found to be, approximately one and half folds higher in gingivitis patients (group II) and three folds higher in chronic periodontitis patients (group III) as compared to healthy subjects (group I). Further, the MCP-1 concentration increased proportionally with the severity of disease in group II and III showing positive correlation with clinical parameters. Thus, its role as an inflammatory biomarker in periodontal disease can be proposed.
机译：目的：初步研究报道了牙周炎患者牙龈沟液（GCF）中单核细胞趋化蛋白-1（MCP-1）的水平较高。目前已经进行了研究以评估其在血清中的浓度，并发现其与牙周健康和疾病的关系。设计：根据牙龈指数（GI），探查囊袋深度（PPD）和临床附着丧失（CAL）将60名受试者分为三组（n = 20）：健康（I组），牙龈炎（II组）和慢性牙周炎（第三组）。第四组（第四组）由治疗后6-8周的第三组的20名受试者组成。缩放和根计划（SRP）]。使用酶联免疫吸附测定（ELISA）对每位患者的血清样本中的MCP-1进行定量。结果：血清中MCP-1的平均浓度在III组最高，即465.80 pg / ml，在I组中最低，即155.20 pg / ml。对于组II（251.60 pg / ml）和组IV（263.20 pg / ml），发现平均MCP-1浓度介于组I和组III所获得的浓度之间。结论：与健康受试者（第一组）相比，发现牙龈炎患者（第二组）的血清MCP-1浓度高约一倍半，而慢性牙周炎患者（第三组）的血清MCP-1浓度高三倍。此外，MCP-1浓度与II组和III组疾病的严重程度成比例地增加，与临床参数呈正相关。因此，可以提出其在牙周疾病中作为炎性生物标志物的作用。

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