...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Association of proinflammatory cytokines with end stage renal disease.
【24h】

Association of proinflammatory cytokines with end stage renal disease.

机译：促炎细胞因子与终末期肾脏疾病的关联。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CONTEXT: Cytokines play an important role in the pathogenesis of kidney disease and its progression to ESRD. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is released by macrophages and lymphocytes and interferon-gamma (IFN-gamma) plays an important pathogenetic role in several inflammatory diseases. OBJECTIVES: We have explored the role of MIF -173 G/C, INF-gamma +874 A/T and INF-gamma CA repeat microsatellite gene polymorphisms as a susceptibility for ESRD. Participants and methods: We genotyped MIF and IFN-gamma gene polymorphisms in 258 patients with ESRD and 569 healthy controls free of any renal disease using PCR-RFLP, gene sequencing and gene scanning methods. RESULTS: The frequency of high producer MIF -173 CC genotype was higher (10.1%) in ESRD than in controls (1.2%) (p=0.0001, OR=8.9; 95%CI=3.8-21.0). It was observed that there was significant differences in the genotype frequencies of the IFN-gamma +874 A/T at genotypic as well as at allelic level (p=0.0023 and p=0.001) among patients and controls. A significant difference was found in the frequency distribution between the two groups at IFN-gamma CA microsatellite polymorphism (p=0.0001) (CA(17))/(CA(17)). Combined analysis revealed a higher risk ( approximately 9-fold) in ESRD patients with high MIF -173 G/C and high INF-gamma +874 A/T protein producing phenotypes. CONCLUSIONS: These results highlight the role of MIF and IFN-gamma in ESRD disease.
机译：背景：细胞因子在肾脏疾病的发病机理及其向ESRD的发展中起着重要作用。巨噬细胞迁移抑制因子（MIF）是一种由巨噬细胞和淋巴细胞释放的促炎细胞因子，干扰素-γ（IFN-γ）在几种炎症性疾病中起重要的致病作用。目的：我们探讨了MIF -173 G / C，INF-γ+874 A / T和INF-γCA重复微卫星基因多态性对ESRD的敏感性。参与者和方法：我们使用PCR-RFLP，基因测序和基因扫描方法，对258例ESRD患者和569名无任何肾脏疾病的健康对照的MIF和IFN-γ基因多态性进行了基因分型。结果：ESRD中高产MIF -173 CC基因型的频率高于对照组（1.2％）（p = 0.0001，OR = 8.9; 95％CI = 3.8-21.0）。观察到在患者和对照中，在基因型以及等位基因水平上，IFN-γ+874 A / T的基因型频率存在显着差异（p = 0.0023和p = 0.001）。发现在IFN-γCA微卫星多态性（p = 0.0001）（CA（17））/（CA（17））上，两组之间的频率分布存在显着差异。组合分析显示，在具有高MIF -173 G / C和高INF-γ+874 A / T蛋白产生表型的ESRD患者中，风险较高（约9倍）。结论：这些结果突出了MIF和IFN-γ在ESRD疾病中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号