The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus.

Postal M; Appenzeller S

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The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus.

机译：肿瘤坏死因子-α（TNF-alpha）在系统性红斑狼疮发病中的作用。

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The Tumor Necrosis Factor-alpha (TNF-alpha) is a pleiotropic cytokine that produces different stimuli in various physiological and pathological conditions. TNF-alpha contributes importantly to the development of T cells, B cells, and dendritic cells. However, TNF-alpha is also a potent inflammatory mediator and apoptosis inducer. The significance of the TNF-alpha involvement in the pathogenesis of systemic lupus erythematosus (SLE) remains controversial. From the genetic standpoint, a number of studies suggest that the TNF-alpha gene polymorphism is involved in the susceptibility of SLE. Moreover, there is a close association between the TNF-alpha gene expression and clinical manifestations. In addition, the increased serum level of TNF-alpha is observed in SLE patients and associated with disease activity and certain systemic manifestations. Treatment with anti-TNF agents is, however, controversial in SLE since induction of antinuclear antibodies, anti-dsDNA, anticardiolipin antibodies, and cases of drug-induced lupus have been observed in rheumatoid arthritis patients. In this context, this study reviewed the importance of TNF-alpha in the pathogenesis of SLE.

机译：肿瘤坏死因子-α（TNF-alpha）是一种多效性细胞因子，在各种生理和病理条件下会产生不同的刺激。 TNF-α对T细胞，B细胞和树突状细胞的发育有重要贡献。但是，TNF-α还是有效的炎症介质和凋亡诱导剂。 TNF-α参与系统性红斑狼疮（SLE）发病机制的意义仍存在争议。从遗传学角度来看，许多研究表明TNF-α基因多态性与SLE的易感性有关。此外，TNF-α基因表达与临床表现之间存在密切的联系。另外，在SLE患者中观察到血清TNF-α水平升高，并且与疾病活动和某些全身表现有关。然而，由于在类风湿性关节炎患者中观察到了抗核抗体，抗dsDNA，抗心磷脂抗体以及药物诱导的狼疮的发生，因此在SLE中使用抗TNF药物的治疗存在争议。在这种情况下，这项研究回顾了TNF-α在SLE发病机理中的重要性。

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《Cytokine》 |2011年第3期|共7页
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Postal M; Appenzeller S;
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1. The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. [J] . Postal M, Appenzeller S Cytokine . 2011,第3期

机译：肿瘤坏死因子-α（TNF-alpha）在系统性红斑狼疮发病中的作用。
2. Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus. [J] . Venegas Pont M, Manigrasso MB, Grifoni SC, Hypertension: An Official Journal of the American Heart Association . 2010,第4期

机译：在系统性红斑狼疮小鼠模型中，肿瘤坏死因子-α拮抗剂依那西普降低血压并保护肾脏。
3. Investigation of cytokine (tumor necrosis factor-alpha, interleukin-6, interleukin-10) concentrations in the cerebrospinal fluid of female patients with multiple sclerosis and systemic lupus erythematosus. [J] . Baraczka K, Pozsonyi T, Ormos G European journal of neurology: the official journal of the European Federation of Neurological Societies . 2004,第1期

机译：女性多发性硬化症和系统性红斑狼疮患者脑脊液中细胞因子（肿瘤坏死因子-α，白细胞介素-6，白细胞介素10）浓度的调查。
4. Tumor Necrosis Factor-alpha (TNF-alpha) Gene -238 Single Nucleotide Polymorphism (SNP) Is Associated with Low TNF-a Production from Peripheral Blood Mononuclear Cells (PBMCs) in Japanese [C] . K. Shuno, M. Aoyama, S. Fudo, Conference on Shock . 2008

机译：肿瘤坏死因子-α（TNF-α）基因-238单核苷酸多态性（SNP）与日本外周血单核细胞（PBMC）的低TNF-A生产相关
5. Studying the pathogenesis of kidney and central nervous system disease in systemic lupus erythematosus. [D] . Gao, Hua-Xin. 2009

机译：研究系统性红斑狼疮的肾脏和中枢神经系统疾病的发病机理。
6. Impaired tumour necrosis factor-alpha (TNF-alpha) production and abnormal B cell response to TNF-alpha in patients with systemic lupus erythematosus (SLE). [O] . K Mitamura, H Kang, Y Tomita, 1991

机译：系统性红斑狼疮（SLE）患者的肿瘤坏死因子-α（TNF-α）产生受损和B细胞对TNF-α的异常反应。
7. Association of a Promoter Polymorphism of Tumor Necrosis Factor-α with Subacute Cutaneous Lupus Erythematosus and Distinct Photoregulation of Transcription1,21Werth VP, Sullivan K: Strong association of a promoter polymorphism of tumor necrosis factors α with a photosensitive form of cutaneous lupus erythematosus. Arthr Rheum 42:S105 1999 (abstr.)2Werth VP, Zhang W, Sullivan K: Role of a promoter polymorphism of tumor necrosis factor-α (TNF-α) in a photosensitive form of lupus erythematosus (LE): clinical association and distinct photoregulation of transcription. J Invest Dermatol 114:770 2000 (abstr.) [O] . Werth Victoria P., Zhang Wei, Dortzbach Kathy, 2000

机译：肿瘤坏死因子-α启动子多态性与亚急性皮肤性红斑狼疮和转录的明显光调节相关1,21Werth VP，Sullivan K：肿瘤坏死因子α的启动子多态性与光敏性皮肤性红斑狼疮有很强的联系。 Arthr Rheum 42：S105 1999（摘要）2沃特VP，张W，沙利文K：肿瘤坏死因子-α（TNF-α）启动子多态性在红斑狼疮（LE）的光敏形式中的作用：临床关联和独特之处转录的光调节。 J投资皮肤病杂志114：770 2000（摘要）

The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus.

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