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首页> 外文期刊>Cytokine >A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma.
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A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma.

机译：肿瘤坏死因子受体II基因的功能多态性与乳腺癌的生存和复发预测有关。

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摘要

OBJECTIVE: Recently, we showed the implication of the polymorphism in tumor necrosis factor-alpha (TNF-alpha) gene in the susceptibility and prognosis of breast carcinoma. TNF-alpha acts through its receptors: types I and II. The TNFRII, expressed on the haematopoietic cells, is the high affinity receptor involved in mediating the biological effects of TNF-alpha. We investigated the susceptibility and prognostic implications of the genetic variation in the TNFRII in breast carcinoma. METHODS: We used the polymerase chain reaction and restriction enzyme digestion to characterize the variation of the TNFRII gene in 300 unrelated Tunisian patients with breast carcinoma and 200 healthy control subjects. Associations of the genetic marker with the rates of the breast carcinoma-specific overall survival and the disease-free survival were assessed. RESULTS: A significant association was found between TNFRII-196M/R heterozygous genotype and breast carcinoma (OR=1.61; P=0.02). This association was more significant in post-menopausal patients (OR=2.41, P=0.0001). The 196R-TNFRII allele showed a significant association with increased overall survival and disease-free survival in breast carcinoma patients. CONCLUSION: Genetic variation in TNFRII may predict the late onset of breast carcinoma, relapse and death for patients with breast carcinoma.
机译：目的：最近，我们显示了肿瘤坏死因子-α（TNF-α）基因的多态性与乳腺癌的易感性和预后有关。 TNF-α通过其受体：I型和II型起作用。在造血细胞上表达的TNFRII是参与介导TNF-α生物学效应的高亲和力受体。我们调查了乳腺癌中TNFRII基因变异的易感性和预后意义。方法：我们使用聚合酶链反应和限制性内切酶消化来表征300例突尼斯乳腺癌患者和200例健康对照者的TNFRII基因的变异。评估遗传标志物与乳腺癌特异性总生存率和无病生存率的相关性。结果：TNFRII-196M / R杂合基因型与乳腺癌之间存在显着相关性（OR = 1.61; P = 0.02）。该关联在绝经后患者中更为显着（OR = 2.41，P = 0.0001）。 196R-TNFRII等位基因与乳腺癌患者的总体生存率提高和无病生存率显着相关。结论：TNFRII的遗传变异可能预示着乳腺癌的晚期发作，复发和死亡。

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