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首页> 外文期刊>Cytokine >Lipid and low-density-lipoprotein apheresis. effects on plasma inflammatory profile and on cytokine pattern in patients with severe dyslipidemia.
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Lipid and low-density-lipoprotein apheresis. effects on plasma inflammatory profile and on cytokine pattern in patients with severe dyslipidemia.

机译：脂质和低密度脂蛋白单采。重度血脂异常患者对血浆炎症谱和细胞因子模式的影响

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摘要

Available evidence on the effects of therapeutic plasmapheresis (TP) techniques and in particular lipid- and LDL-apheresis (LDL-a) on plasmatic inflammatory mediators including cytokines were reviewed. Studies on this issue are not numerous. However, the review of existing evidence clearly suggests an active role of apheresis on the profile of inflammatory molecules and on cytokine pattern in plasma. These non-lipid-lowering effects can be defined to some extent pleiotropic or pleiotropic-equivalent. Although further studies are desirable, the data reported in this review confirm that lipid- and LDL-a not only show acute lipid-lowering and cholesterol-lowering effects, but also efficacy in reducing several proinflammatory peptides, including cytokines. This effect was not related apparently to lipids and lipoproteins reduction. Thus, TP (lipid- and LDL-a), commonly utilized in the treatment of severe genetically determined lipid disorders, unresponsive to hypolipidemic drugs, offers new possibilities of interpretation of its role in the mechanisms leading to the blockade of atherosclerotic lesion development and progression. The ability of TP on short-term to induce such a profound change in the plasmatic metabolic and inflammatory profiles must be kept in mind in the treatment of acute coronary syndromes, before and after interventions of coronary revascularization, and in the acute phase of cerebrovascular ischemia, at least in patients with severe dyslipidemia. Further studies are needed, in particular aimed at assessing if circulating cytokines may be downregulated by TP not only by direct removal, but through indirect effects on both gene translation and transcription perhaps via the cytokine receptor function.
机译：审查了有关治疗性血浆置换（TP）技术，特别是脂质和LDL置换（LDL-a）对血浆炎性介质（包括细胞因子）的影响的现有证据。关于这个问题的研究并不多。但是，对现有证据的回顾清楚地表明，血液分离在血浆中的炎症分子和细胞因子模式中起着积极的作用。这些非降脂作用可以在一定程度上定义为多效或等效的。尽管需要进一步研究，但本综述中报道的数据证实脂质和LDL-a不仅显示出急性降脂和降胆固醇作用，而且还具有减少包括细胞因子在内的几种促炎肽的功效。这种作用显然与脂质和脂蛋白的减少无关。因此，TP（脂质和LDL-a）通常用于治疗严重的遗传决定的脂质疾病，对降血脂药无反应，为解释其在导致动脉粥样硬化病变发展和进展的机制中的作用提供了新的可能性。 。在急性冠状动脉综合征的治疗中，在冠状动脉血运重建干预之前和之后以及在脑血管缺血的急性期中，必须牢记TP短期诱导血浆代谢和炎性分布发生如此深刻变化的能力，至少在患有严重血脂异常的患者中。需要进一步的研究，特别是旨在评估循环中的细胞因子是否不仅可以通过直接去除，而且可以通过可能通过细胞因子受体功能对基因翻译和转录产生的间接作用而被TP下调。

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