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首页> 外文期刊>Cytokine >Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals
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Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals

机译：炎症相关基因RANTES和CCR5的功能多态性变异在长寿人群中的分布

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摘要

Although persistent inflammation has been related to unsuccessful aging, a pro-inflammatory status is the common phenotype in older people. To assess for a genetic component in the inflammatory status of the oldest we studied the distribution of two polymorphic chemokine pathway genes, RANTES and CCR5, in elderly. RANTES -403G/A and RANTES Int1.1T/C polymorphisms and CCR5Δ32 polymorphism were genotyped in 104 elderly and 110 controls. RANTES -403A and RANTES Int1.1C alleles have been associated with pro-inflammatory and anti-inflammatory status, respectively. CCR5Δ32 abrogates functional receptor expression of the pro-inflammatory CCR5-mediated action. Prevalence of RANTES -403G allele, associated in other studies with high RANTES production, was reduced in elderly males, compared with controls. In addition, RANTES pro-inflammatory haplotype -403A-Int1.1T was overrepresented in elderly males, while RANTES anti-inflammatory haplotype -403G-Int1.1C was overrepresented in elderly females. Our results suggest a sex-specific RANTES inflammatory genetic determinant that could contribute to the known sex-related differences in aging.
机译：尽管持续性炎症与衰老不成功有关，但促炎状态是老年人的常见表型。为了评估最老的炎症状态中的遗传成分，我们研究了老年人中两个多态性趋化因子途径基因RANTES和CCR5的分布。 RANTES -403G / A和RANTES Int1.1T / C多态性和CCR5Δ32多态性在104名老年人和110名对照中进行了基因分型。 RANTES -403A和RANTES Int1.1C等位基因分别与促炎和抗炎状态相关。 CCR5Δ32消除了促炎性CCR5介导的功能的功能性受体表达。与对照组相比，老年男性的RANTES -403G等位基因的患病率在其他研究中与高RANTES产生有关。另外，在老年男性中，RANTES促炎性单倍体-403A-Int1.1T的代表过多，而在老年女性中，RANTES抗炎性单倍体-403G-Int1.1C的代表过度。我们的研究结果表明，性别特定的RANTES炎症遗传决定因素可能会导致已知的性别相关衰老差异。

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