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首页> 外文期刊>Cytokine >Enter at your own risk: How enteroviruses navigate the dangerous world of pattern recognition receptor signaling
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Enter at your own risk: How enteroviruses navigate the dangerous world of pattern recognition receptor signaling

机译：输入风险自负：肠病毒如何驾驭模式识别受体信号传导的危险世界

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摘要

Enteroviruses are the most common human viral pathogens worldwide. This genus of small, non-enveloped, single stranded RNA viruses includes coxsackievirus, rhinovirus, echovirus, and poliovirus species. Infection with these viruses can induce mild symptoms that resemble the common cold, but can also be associated with more severe syndromes such as poliomyelitis, neurological diseases including aseptic meningitis and encephalitis, myocarditis, and the onset of type I diabetes. In humans, polarized epithelial cells lining the respiratory and/or digestive tracts represent the initial sites of infection by enteroviruses. Control of infection in the host is initiated through the engagement of a variety of pattern recognition receptors (PRRs). PRRs act as the sentinels of the innate immune system and serve to alert the host to the presence of a viral invader. This review assembles the available data annotating the role of PRRs in the response to enteroviral infection as well as the myriad ways by which enteroviruses both interrupt and manipulate PRR signaling to enhance their own replication, thereby inducing human disease.
机译：肠病毒是全世界最常见的人类病毒病原体。小型，无包膜的单链RNA病毒属包括柯萨奇病毒，鼻病毒，回声病毒和脊髓灰质炎病毒。感染这些病毒可诱发类似于普通感冒的轻度症状，但也可能与更严重的综合症（如脊髓灰质炎，包括无菌性脑膜炎和脑炎的神经系统疾病，心肌炎和I型糖尿病的发作）相关。在人类中，位于呼吸道和/或消化道内的极化上皮细胞代表了肠道病毒感染的最初部位。宿主感染的控制是通过多种模式识别受体（PRR）的参与而启动的。 PRR充当先天免疫系统的前哨，并提醒宿主病毒感染者的存在。这篇综述收集了一些有用的数据，这些数据说明了PRR在对肠道病毒感染的应答中的作用，以及肠病毒中断和操纵PRR信号以增强自身复制从而诱发人类疾病的多种方式。

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