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首页> 外文期刊>Cytokine >The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain
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The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain

机译：IL-17 G-152A单核苷酸多态性与西班牙北部的肺结核有关

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Background: Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculosis, but no relationship has been found with another single nucleotide polymorphism (SNP) in IL-17A gene (rs2275913). Methods: To assess if rs2275913 (G-152A) SNP, could be associated with susceptibility to pulmonary tuberculosis (PTB) in a genetically homogeneous Caucasian population, we analyzed if its allele and genotype frequencies were statistically significant in a case-control study. One hundred and ninety-two patients with active PTB and 266 blood healthy donors were enrolled in this study. Results: The frequency of the GG versus GA. +. AA genotype was significantly more frequent in patients with PTB than in control subjects assuming a dominant model (50.52% versus 39.10% respectively, OR. = 1.59, 95%CI. = 1.09-2.31, p= 0.015). Despite patients with PTB had higher serum IL-17 levels, we did not find an association of this SNP with IL-17 ex vivo production after stimulation with Mycobacterium tuberculosis (Mtb) antigens or phytohemagglutinin (PHA). Conclusion: Our results would suggest an association between IL-17A rs2275913 - 152G allele and GG genotype with susceptibility to PTB for the first time.
机译：背景：白细胞介素17（IL-17）在结核感染的早期阶段被诱导，在防御分枝杆菌感染中起重要作用。迄今为止，只有一项在中国汉族人群中进行的研究发现IL-17F序列变异与结核病易感性之间存在关联，但未发现与IL-17A基因的另一个单核苷酸多态性（SNP）相关（rs2275913）。方法：为了评估rs2275913（G-152A）SNP是否可能与遗传上同质的白种人人群中的肺结核（PTB）易感性相关，我们在病例对照研究中分析了其等位基因和基因型频率是否具有统计学意义。这项研究纳入了192名活动性PTB患者和266名血液健康捐献者。结果：GG相对于GA的频率。 +。 PTB患者的AA基因型显着高于对照组（假设为显性模型）（分别为50.52％和39.10％，OR。= 1.59，95％CI。= 1.09-2.31，p = 0.015）。尽管PTB患者的血清IL-17水平较高，但在结核分枝杆菌（Mtb）抗原或植物血凝素（PHA）刺激后，我们并未发现该SNP与IL-17的体外产生有关。结论：我们的研究结果首次提示IL-17A rs2275913-152G等位基因与GG基因型与PTB易感性相关。

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