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Serum levels of interleukin-2 predict the recurrence of atrial fibrillation after pulmonary vein ablation

机译：血清白细胞介素2水平预测肺静脉消融后房颤的复发

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Aims: Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exists between inflammation and the outcome of catheter ablation of AF. Methods: We studied 44 patients with paroxysmal AF who underwent catheter ablation. Patients with structural heart disease, coronary artery or valve disease, active inflammatory disease, known or suspected neoplasm, endocrinopathies, or exposure to anti-inflammatory drugs were excluded. All study participants underwent evaluation with a standardized protocol, including echocardiography, and cytokine levels of interleukin-2, interleukin-4, interleukin-6, interleukin-10, tumour necrosis factor-alpha, and gamma-interferon determination before procedure. Clinical and electrocardiographic follow-up were performed with Holter-ECG at 3, 6 and 12. months in order to know if sinus rhythm was maintained. Results: After catheter ablation of the 44 patients included (53. ±. 10. years, 27.3% female), all patients returned to sinus rhythm. During the first year of follow-up seven patients (15.9%) experienced recurrence of AF. The demographics, clinical and echocardiographic features, and pharmacological treatments of these patients were similar to those who maintained sinus rhythm. The only independent factor predictive of recurrence of AF was an elevated level of IL-2 (OR 1.18, 95% CI 1.12-1.38). Conclusions: High serum levels of interleukin-2, a pro-inflammatory non-vascular cytokine, are associated with the recurrence of AF in patients undergoing catheter ablation.
机译：目的：白介素-2在某些类型的癌症中具有显着的抗肿瘤活性，并与房颤（AF）的发生有关。另外，最近发作的AF中的IL-2血清水平与药物心脏复律结果相关。我们评估了炎症与房颤导管消融结局之间存在联系的假设。方法：我们研究了44例阵发性AF患者，他们接受了导管消融术。患有结构性心脏病，冠状动脉或瓣膜疾病，活动性炎症性疾病，已知或疑似肿瘤，内分泌病变或接触抗炎药的患者被排除在外。所有研究参与者均接受标准化方案的评估，包括超声心动图，术前测定白细胞介素2，白细胞介素4，白细胞介素6，白细胞介素10，肿瘤坏死因子-α和γ-干扰素的细胞因子水平。用Holter-ECG在3、6和12个月进行临床和心电图随访，以了解是否维持窦性心律。结果：包括44位患者（53.±.10岁，女性占27.3％）的导管消融后，所有患者均恢复了窦性心律。在随访的第一年中，有7名患者（15.9％）出现了AF复发。这些患者的人口统计学，临床和超声心动图特征以及药物治疗与维持窦性心律的患者相似。预测房颤复发的唯一独立因素是IL-2水平升高（OR 1.18，95％CI 1.12-1.38）。结论：血浆高水平的白细胞介素2是一种促炎性非血管细胞因子，与导管消融患者房颤的复发有关。

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