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首页> 外文期刊>Cytokine >Necrotic cell death and suppression of T-cell immunity characterized acute liver failure due to drug-induced liver injury
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Necrotic cell death and suppression of T-cell immunity characterized acute liver failure due to drug-induced liver injury

机译：药物性肝损伤引起的急性肝衰竭是坏死细胞死亡和T细胞免疫抑制的特征

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Background & aims: The aim of this study was to investigate the clinical characteristics and pathophysiology of drug-induced liver injury (DILI) - acute liver failure (ALF). Methods: The patients with acute liver injury (ALI) including ALF from 2009 to 2014 were analyzed. The hepatic encephalopathy (HE) development rate was compared with the findings from a national survey in Japan. The serum cytokines levels and the findings of a liver function test were evaluated in the DILI patients. Results: The HE development rate substantially decreased for autoimmune hepatitis (AIH) - and undetermined cause-induced ALI owing to the early prediction system, but not in DILI-ALI. Among the DILI-ALF and AIH-ALF cases, the CK-18 fragment (1480.1 U/L, 3945.4 U/L), IL-8 (82.9 pg/mL, 207.5 pg/mL), IP-10 (1379.6 pg/mL, 3731.2 pg/mL) and MIP-1 beta (1017.7 pg/mL, 2273.3 pg/mL) levels were lower in the DILI-ALF cases. Among the DILI-ALI and DILI-ALF cases, IL-4 (19.8 pg/mL, 25.4 pg/mL) and RANTES (14028.0 pg/mL, 17804.7 pg/mL) were higher in DILI-ALI, and HMGB-1 (397.1 pg/mu L, 326.2 pg/mu L) and HGF (2.41 ng/mL, 0.55 ng/mL) were higher in DILI-ALF. We observed that HGF independently associated with DLI-ALF development. Conclusions: Despite the low grade apoptosis and inflammation, DILI patients progressed to ALF comparable with that of the AIH patients. (C) 2016 Elsevier Ltd. All rights reserved.
机译：背景与目的：本研究的目的是研究药物性肝损伤（DILI）-急性肝衰竭（ALF）的临床特征和病理生理。方法：对2009年至2014年包括ALF在内的急性肝损伤（ALI）患者进行分析。将肝性脑病（HE）的发生率与日本的一项全国调查结果进行了比较。在DILI患者中评估血清细胞因子水平和肝功能检查结果。结果：由于早期预测系统，自身免疫性肝炎（AIH）的HE发生率显着下降，而原因未明的ALI引起的ALI尚未确定。在DILI-ALF和AIH-ALF病例中，CK-18片段（1480.1 U / L，3945.4 U / L），IL-8（82.9 pg / mL，207.5 pg / mL），IP-10（1379.6 pg / mL）在DILI-ALF病例中，mL（3731.2 pg / mL）和MIP-1 beta（1017.7 pg / mL，2273.3 pg / mL）水平较低。在DILI-ALI和DILI-ALF病例中，DILI-ALI和HMGB-1（19.8 pg / mL，25.4 pg / mL）和RANTES（14028.0 pg / mL，17804.7 pg / mL）较高。在DILI-ALF中，397.1 pg /μL，326.2 pg /μL）和HGF（2.41 ng / mL，0.55 ng / mL）更高。我们观察到HGF与DLI-ALF的发展独立相关。结论：尽管低级别的细胞凋亡和炎症反应，DILI患者发展为ALF的程度可与AIH患者媲美。 （C）2016 Elsevier Ltd.保留所有权利。

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