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首页> 外文期刊>Brain research bulletin >Caudate nucleus neurons participate in methylphenidate function: Behavioral and neuronal recordings from freely behaving adolescent rats
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Caudate nucleus neurons participate in methylphenidate function: Behavioral and neuronal recordings from freely behaving adolescent rats

机译：尾状核神经元参与甲基酚酯：自由表现青少年大鼠的行为和神经元记录

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Methylphenidate (MPD) is the most commonly prescribed psychostimulant for the treatment of attention-deficit hyperactivity disorder (ADHD). MPD acts on brain structures of the reward/motivation system, including the caudate nucleus (CN). The objective of this study was to investigate the acute and chronic dose response effects of MPD on CN neurons in freely behaving adolescent rats. Semi-microelectrodes were implanted into the CN of one hundred and sixty-three adolescent male Sprague-Dawley rats. On experimental day one (ED1), each rat was injected with 0.8?ml saline followed by an injection of MPD (0.6, 2.5, or 10.0?mg/kg). Behavioral and neuronal recordings of 60?min followed each injection. Throughout ED2-6, each rat remained in its home cage and received daily injections of a specific dose of MPD. ED7-9 consisted of a three-day washout period during which no injections were given. On the last day (ED10), each rat was returned to the testing chamber in its home cage and an identical protocol was performed as on ED1. The same repetitive (i.e. chronic) dose of MPD elicited behavioral sensitization in some animals and behavioral tolerance in others. After chronic MPD exposure, CN units recorded from rats expressing behavioral sensitization responded mainly with increased neuronal firing rates. Conversely, rats expressing behavioral tolerance responded mainly with decreased neuronal firing rates. These findings suggest a direct correlation between the behavioral and CN neurophysiological response to chronic MPD in adolescent animals.
机译：甲基酚（MPD）是治疗注意力缺陷多动障碍（ADHD）的最常见规定的精神刺激剂。 MPD作用于奖励/动机系统的脑结构，包括尾部核（CN）。本研究的目的是探讨MPD对CN神经元的急性和慢性剂量反应作用在自由行为青少年大鼠中。将半微电极植入一百六十三六十三六十三次雄性Sprague-Dawley大鼠的CN中。在实验日（ED1）上，将每只大鼠注射0.8×ml盐水，然后注射MPD（0.6,2.5或10.0×mg / kg）。每次注射术后60Ω分钟的行为和神经元记录。在整个ED2-6中，每只老鼠仍然在其家庭笼子中，并接受了每日注射特定剂量的MPD。 ED7-9由三天的洗涤期组成，在此期间没有给予注射。在最后一天（ED10）上，每个大鼠在其家庭笼子中返回到测试室，并且在ED1上进行相同的协议。在某些动物中具有相同的重复（即慢性）剂量的MPD引发行为致敏和其他动物的行为耐受性。在慢性MPD暴露后，从表达行为敏化的大鼠记录的CN单位主要是随着神经元烧制率的增加而作出的反应。相反，表达行为耐受性的大鼠主要是由于神经元烧制率降低。这些发现表明，在青少年动物中对慢性MPD的行为和CN神经生理反应之间的直接相关性。

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