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Caudate neuronal recording in freely behaving animals following acute and chronic dose response methylphenidate exposure

机译:急性和慢性剂量反应哌醋甲酯暴露后自由行为动物的尾状神经元记录

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摘要

The misuse and abuse of the psychostimulant, methylphenidate (MPD) the drug of choice in the treatment of attention deficit hyperactivity disorder (ADHD) has seen a sharp uprising in recent years among both youth and adults for its cognitive enhancing effects and for recreational purposes. This uprise in illicit use has lead to many questions concerning the long-term consequences of MPD exposure. The objective of this study was to record animal behavior concomitantly with the caudate nucleus (CN) neuronal activity following acute and repetitive (chronic) dose response exposure to methylphenidate (MPD). A saline control and three MPD dose (0.6, 2.5, and 10.0 mg/kg) groups were used.
机译:精神兴奋剂哌醋甲酯(MPD)的滥用和滥用是治疗注意力缺陷多动障碍(ADHD)的首选药物,近年来,年轻人和成年人因其认知增强作用和娱乐目的而急剧起义。非法使用的增加导致了许多有关MPD暴露的长期后果的问题。这项研究的目的是记录暴露于哌醋甲酯(MPD)的急性和重复(慢性)剂量反应后动物的行为以及尾状核(CN)的神经元活动。使用盐水对照组和三个MPD剂量(0.6、2.5和10.0 mg / kg)组。

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