...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?
【24h】

Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?

机译：巨噬细胞炎性蛋白1α：先天免疫与家族性地中海热之间的联系？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha (MIP-1alpha) were assessed in the patients and the controls, along with other parameters of disease activity, i.e., fibrinogen, C-reactive protein and erythrocyte sedimentation rate. Serum MIP-1alpha levels of the patients with FMF in acute attack period were significantly higher than the patients in remission and healthy controls (p=0.02 and p=0.038, respectively). MIP-1alpha levels were weakly correlated with CRP (r=0.32, p=0.032) levels. MIP-1alpha may have a role in the pathogenesis of FMF attacks. MIP-1alpha and other chemokines may constitute a link between the innate immune system and FMF.
机译：这项研究的目的是调查家族性地中海热（FMF）中趋化因子与炎症之间的关系。该研究包括49例FMF患者（缓解期41例，急性发作期8例）和20名健康对照。评估患者和对照组的血清巨噬细胞炎性蛋白-1α（MIP-1alpha）水平，以及疾病活动性的其他参数，即纤维蛋白原，C反应蛋白和红细胞沉降率。急性发作期FMF患者的血清MIP-1alpha水平显着高于缓解期和健康对照组的患者（分别为p = 0.02和p = 0.038）。 MIP-1alpha水平与CRP水平弱相关（r = 0.32，p = 0.032）。 MIP-1alpha可能在FMF发作的发病机制中起作用。 MIP-1alpha和其他趋化因子可能构成先天免疫系统和FMF之间的联系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号