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首页> 外文期刊>Cytokine >Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome.
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Elevated circulating levels of macrophage migration inhibitory factor in polycystic ovary syndrome.

机译：多囊卵巢综合征中巨噬细胞迁移抑制因子的循环水平升高。

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Women with polycystic ovary syndrome (PCOS) have chronic low level inflammation which can increase the risk of atherogenesis. We evaluated the status of circulating macrophage migration inhibitory factor (MIF), a proinflammatory cytokine involved in atherogenesis, in women with PCOS and weight-matched controls. Two-way analysis of variance models adjusted for age were fit to evaluate the effect of PCOS status (PCOS vs. controls) and weight-class (obese vs. lean) on MIF and other parameters. MIF levels were significantly (p<0.001) higher in women with PCOS (lean: 37.7+/-10.6 ng/ml; obese: 54.6+/-15.2 ng/ml) compared to controls (lean: 4.8+/-0.6 ng/ml; obese: 17.5+/-8.0 ng/ml) regardless of weight-class. CRP levels were significantly (p<0.001) higher in obese subjects (PCOS: 6.2+/-1.9 mg/l; controls: 6.7+/-1.4 mg/l) compared to lean subjects (PCOS: 0.9+/-0.4 mg/l; controls: 0.2+/-01 mg/l) after controlling for PCOS status. MIF levels directly correlated with % truncal fat (r=0.41, p<0.05), and plasma levels of CRP (r=0.42, p=0.05), LH (r=0.45, p=0.04), testosterone (r=0.53, p<0.008), androstendione (r=0.58, p<0.005). IS(OGTT) inversely correlated with plasma levels of MIF (r=-0.51, p<0.02) and CRP (r=-0.73, p<0.001). Circulating MIF is elevated in PCOS independent of obesity, but both PCOS and obesity contribute to a proatherogenic state. In PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis.
机译：多囊卵巢综合征（PCOS）的妇女患有慢性低水平炎症，可能增加动脉粥样硬化的发生风险。我们评估了患有PCOS和体重匹配的女性的循环巨噬细胞迁移抑制因子（MIF）（一种参与动脉粥样硬化形成的促炎细胞因子）的状态。调整了针对年龄调整的方差模型的双向分析，以评估PCOS状态（PCOS与对照组）和权重等级（肥胖与瘦肉）对MIF和其他参数的影响。与对照组相比，PCOS女性（瘦：37.7 +/- 10.6 ng / ml;肥胖：54.6 +/- 15.2 ng / ml）的MIF水平显着更高（p <0.001）（瘦：4.8 +/- 0.6 ng / ml）。 ml;肥胖：17.5 +/- 8.0 ng / ml），无论体重级别如何。与瘦弱的受试者（PCOS：0.9 +/- 0.4 mg / l）相比，肥胖受试者（PCOS：6.2 +/- 1.9 mg / l;对照组：6.7 +/- 1.4 mg / l）的CRP水平显着（p <0.001）高l;控制：控制PCOS状态后为0.2 +/- 01 mg / l）。 MIF水平与矮牵牛百分比（r = 0.41，p <0.05）和血浆CRP（r = 0.42，p = 0.05），LH（r = 0.45，p = 0.04），睾丸激素（r = 0.53， p ＜0.008）和雄烯二酮（r ＝ 0.58，p ＜0.005）。 IS（OGTT）与MIF（r = -0.51，p <0.02）和CRP（r = -0.73，p <0.001）的血浆水平呈负相关。独立于肥胖症，PCOS中的循环MIF升高，但PCOS和肥胖症均导致动脉粥样硬化。在PCOS中，腹部肥胖和雄激素过多可能加剧动脉粥样硬化的风险。

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