Extensive serum biomarker analysis in patients with ST segment elevation myocardial infarction (STEMI)

Zhang Yi; Lin Peiyi; Jiang Huilin; Xu Jieling; Luo Shuhong; Mo Junrong; Li Yunmei; Chen Xiaohui

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Extensive serum biomarker analysis in patients with ST segment elevation myocardial infarction (STEMI)

机译：ST段抬高型心肌梗死（STEMI）患者的广泛血清生物标志物分析

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ST segment elevation myocardial infarction (STEMI) is one of the leading causes of morbidity and mortality and some characteristics of STEMI are poorly understood. The aim of the present study is to detect protein expression profiles in the serum of STEMI patients, and to identify biomarkers for this disease. Cytokine profiles of serum from STEMI patients and healthy controls were analyzed with a semi-quantitative human antibody array for 174 proteins, and the results showed blood serum concentrations of 21 cytokines differed considerably between STEMI patients and healthy subjects. In the next phase, a sandwich ELISA kit individually validated eight biomarker results from 21 of the microarray experiments. Clinical validation demonstrated a significant increase of BNDF, PDGF-AA and MMP-9 in patients with AMI. Meanwhile, BNDF, PDGF-AA and MMP-9 distinguished AMI patients from healthy controls with a mean area under the receiver operating characteristic (ROC) curves of 0.870, 0.885, and 0.81, respectively, with diagnostic cut-off points of 0.688 ng/mL, 297.86 ng/mL and 690.066 ng/mL. Our study indicated that these three cytokines were up-regulated in STEMI samples, and may hold promise for the assessment of STEMI. (C) 2015 Elsevier Ltd. All rights reserved.

机译：ST段抬高型心肌梗死（STEMI）是发病率和死亡率的主要原因之一，人们对STEMI的某些特征了解甚少。本研究的目的是检测STEMI患者血清中的蛋白质表达谱，并鉴定该疾病的生物标志物。用半定量人抗体阵列分析了174种STEMI患者和健康对照者血清的细胞因子谱，结果显示STEMI患者和健康受试者的血清中21种细胞因子的浓度存在显着差异。在下一阶段，夹心ELISA试剂盒分别验证了21项微阵列实验中的8个生物标志物结果。临床验证表明，AMI患者的BNDF，PDGF-AA和MMP-9显着增加。同时，BNDF，PDGF-AA和MMP-9将AMI患者与健康对照者区分开，其平均面积在接受者操作特征（ROC）曲线下分别为0.870、0.885和0.81，诊断截止点为0.688 ng / mL，297.86 ng / mL和690.066 ng / mL。我们的研究表明，这三种细胞因子在STEMI样品中被上调，可能为STEMI的评估提供希望。（C）2015 Elsevier Ltd.保留所有权利。

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《Cytokine》 |2015年第2期|共7页
作者
Zhang Yi; Lin Peiyi; Jiang Huilin; Xu Jieling; Luo Shuhong; Mo Junrong; Li Yunmei; Chen Xiaohui;
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正文语种 eng
中图分类细胞生物学;
关键词
Acute myocardial infarction (AMI); Serum cytokine; Antibody array; STEMI;

机译：急性心肌梗死;血清细胞因子;抗体阵列;STEMI;

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1. Extensive serum biomarker analysis in patients with ST segment elevation myocardial infarction (STEMI) [J] . Zhang Yi, Lin Peiyi, Jiang Huilin, Cytokine . 2015,第2期

机译：ST段抬高型心肌梗死（STEMI）患者的广泛血清生物标志物分析
2. Prognostic performance of multiple biomarkers in patients with non-ST-segment elevation acute coronary syndrome: Analysis from the MERLIN-TIMI 36 trial (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes-Thrombolysis in Myocardial Infarction 36) [J] . OMalleyR.G., BonacaM.P., SciricaB.M., Journal of the American College of Cardiology . 2014,第16期

机译：非ST段抬高的急性冠脉综合征患者中多种生物标志物的预后性能：来自MERLIN-TIMI 36试验的分析（雷诺嗪对非ST段抬高的急性冠状动脉综合征-心肌梗塞血栓溶解的局部缺血代谢效率更高）
3. N-Acetylcysteine Effects on Transforming Growth Factor-β and Tumor Necrosis Factor-α Serum Levels as Pro-Fibrotic and Inflammatory Biomarkers in Patients Following ST-Segment Elevation Myocardial Infarction [J] . Azita Hajhossein Talasaz, Hossein Khalili, Yaser Jenab, Drugs in R&D . 2013,第3期

机译：N-乙酰半胱氨酸对ST段抬高型心肌梗死患者转化生长因子-β和肿瘤坏死因子-α血清水平作为促纤维化和炎性生物标志物的影响
4. Early Diagnosis and Automated Analysis of Myocardial Infarction (STEMI) by Detection of ST Segment Elevation Using Wavelet Transform and Feature Extraction [C] . Anirudha V Bharadwaj, Sripad M Upadhyaya, Sharath L, 2018 International Conference on Design Innovations for 3Cs Compute Communicate Control . 2018

机译：小波变换和特征提取检测ST段抬高对心肌梗死（STEMI）的早期诊断和自动分析
5. Evaluation of ST elevation myocardial infarction (STEMI) patient care stakeholders' perceptions on paramedic-based pre-hospital management of STEMI [D] . Rajabali, Naheed Amirali 2007

机译：ST升高心肌梗死（STEMI）患者护理利益相关者对基于护理人员的疗养主义院前管理的看法
6. N-Acetylcysteine Effects on Transforming Growth Factor-β and Tumor Necrosis Factor-α Serum Levels as Pro-Fibrotic and Inflammatory Biomarkers in Patients Following ST-Segment Elevation Myocardial Infarction [O] . Azita Hajhossein Talasaz, Hossein Khalili, Yaser Jenab, 2013

机译：N-乙酰半胱氨酸对ST段抬高型心肌梗死患者转化生长因子-β和肿瘤坏死因子-α血清水平作为促纤维化和炎症生物标志物的影响
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Extensive serum biomarker analysis in patients with ST segment elevation myocardial infarction (STEMI)

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