Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

Oakes Victoria; Torralba Johana; Rujas Edurne; Nieva Jose L.; Domene Carmen; Apellaniz Beatriz

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Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

机译：通过GP41跨膜结构域支架暴露于HIV-1广泛中和抗体10E8 MPER表位

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摘要

The 10E8 antibody achieves near-pan neutralization of HIV-1 by targeting the remarkably conserved gp41 membrane-proximal external region (MPER) and the connected transmembrane domain (TMD) of the HIV-1 envelope glycoprotein (Env). Thus, recreating the structure that generates 10E8-like antibodies is a major goal of the rational design of anti-HIV vaccines. Unfortunately, high-resolution information of this segment in the native Env is lacking, limiting our understanding of the behavior of the crucial 10E8 epitope residues.

机译：通过靶向HIV-1包膜糖蛋白（ENV）的显着保守的GP41膜 - 近端外部区域（MPER）和连接的跨膜结构域（ENV），10E8抗体通过靶向显着保守的GP41膜 - 近端外部区域（MPER）和连接的跨膜结构域（TMD）来实现HIV-1的接近平移中和。因此，重新创造产生10E8样抗体的结构是抗HIV疫苗的理性设计的主要目标。遗憾的是，缺乏本机环境中该段的高分辨率信息，限制了我们对关键10E8表位残留物的行为的理解。

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来源
《Biochimica et biophysica acta. Biomembranes》 |2018年第6期|共13页
作者
Oakes Victoria; Torralba Johana; Rujas Edurne; Nieva Jose L.; Domene Carmen; Apellaniz Beatriz;
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作者单位

Kings Coll London Dept Chem Britannia House 7 Trinity St London SE1 1DB England;

Univ Basque Country UPV EHU Biofis Inst Biochem &

Mol Biol Dept CSIC Bilbao 48080 Spain;

Univ Basque Country UPV EHU Biofis Inst Biochem &

Mol Biol Dept CSIC Bilbao 48080 Spain;

Univ Basque Country UPV EHU Biofis Inst Biochem &

Mol Biol Dept CSIC Bilbao 48080 Spain;

Univ Bath Dept Chem 1 South Bldg Claverton Down Rd Bath BA2 7AY Avon England;

Univ Basque Country UPV EHU Biofis Inst Biochem &

Mol Biol Dept CSIC Bilbao 48080 Spain;

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原文格式 PDF
正文语种 eng
中图分类生物膜的结构和功能;
关键词
Molecular dynamics simulation; Transmembrane domain; Antigenicity; Vaccine development; HIV-1;

机译：分子动力学模拟;跨膜结构域;抗原;疫苗开发;HIV-1;

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专利

1. Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds [J] . Oakes Victoria, Torralba Johana, Rujas Edurne, Biochimica et biophysica acta. Biomembranes . 2018,第6期

机译：通过GP41跨膜结构域支架暴露于HIV-1广泛中和抗体10E8 MPER表位
2. Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8 [J] . Sutar Jyoti, Padwal Varsha, Sonawani Archana, Virus Research: An International Journal of Molecular and Cellular Virology . 2019,第1期

机译：初级HIV-1印度亚型C序列近端外部区域对近中和抗体4E10和10E8的相互作用近外区域的影响
3. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. [J] . Sun ZY, Oh KJ, Kim M, Immunity . 2008,第1期

机译：HIV-1广泛中和抗体从病毒膜上扭曲的gp41胞外域区域提取其表位。
4. Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins [C] . Wataru Nomera, Toru Nakahara, Chie Hashimoto American Peptide Symposium . 2011

机译：基于HIV-1包络蛋白动态结构的重塑诱导中和抗体的HIV GP41三聚体模拟物的合成
5. Elicitation of antibody responses against the HIV-1 gp41 Membrane Proximal External Region (MPER). [D] . Cheng, Yuxing. 2014

机译：引发针对HIV-1 gp41膜近端外部区域（MPER）的抗体反应。
6. Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice [O] . Milan Kuchař, Petr Kosztyu, Veronika Daniel Lišková, 2021

机译：Myomedin支架变体靶向10E8 HIV-1宽度中和抗体模拟GP41表位和小鼠中的引发HIV-1病毒中和血清
7. HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane [O] . Sun Zhen-Yu J., Oh Kyoung Joon, Kim Mikyung, 2008

机译：HIV-1广泛中和抗体从病毒膜上一个弯曲的gp41 Ectodomain区提取其表位。

Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

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