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Dysregulation of cellular microRNAs by human oncogenic viruses - Implications for tumorigenesis

机译:人致癌病毒细胞微小瘤的失调 - 对肿瘤发生的影响

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Infection with certain animal and human viruses, often referred to as tumor viruses, induces oncogenic processes in their host. These viruses can induce tumorigenesis through direct and/or indirect mechanisms, and the regulation of microRNAs expression has been shown to play a key role in this process. Some human oncogenic viruses can express their own microRNAs; however, they all can dysregulate the expression of cellular microRNAs, facilitating their respective life cycles. The modulation of cellular microRNAs expression brings consequences to the host cells that may lead to malignant transformation, since microRNAs regulate the expression of genes involved in oncogenic pathways. This review focus on the mechanisms used by each human oncogenic virus to dysregulate the expression of cellular microRNAs, and their impact on tumorigenesis.
机译:用某些动物和人类病毒感染,通常称为肿瘤病毒,诱导其宿主中的致癌过程。 这些病毒可以通过直接和/或间接机制诱导肿瘤内肌,并且已经显示了微小RNA表达的调节在该过程中发挥关键作用。 一些人类致癌病毒可以表达自己的小罗风; 然而,它们都能使细胞微小RORNA的表达,促进它们各自的生命周期。 蜂窝微大罗氏酶的调节为可能导致恶性转化的宿主细胞带来后果,因为MicroRNAS调节致癌途径所涉及的基因的表达。 本综述重点是每种人类致癌病毒使用的机制,以使细胞微大稻草的表达及其对肿瘤发生的影响。

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