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From pathogenesis to clinical practice: Emerging medical treatments for endometriosis

机译：从发病机制到临床实践：子宫内膜异位症的新兴医学治疗

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Endometriosis is a chronic disease, and a lifelong management plan should be developed by using pharmacological treatment and surgical procedures. The pathogenesis of endometriosis is complicated and has not been definitively established. The mechanisms involved are numerous, and their understanding is constantly evolving. Currently, the first-line drugs act by blocking ovarian function, creating an hypoestrogenic environment. The blockade of estrogen secretion and receptor activity and the activation of progesteron receptors are the main target of several current drugs, as well as those under development. The oral GnRH antogonists, the aromatase inhibitors, SERMs, and SPRMs are the hormonal drugs currently studied for treating endometriosis. The increasing knowledge of the pathogenesis has allowed the development of new treatments. The most studied are the anti-inflammatory drugs, starting from the new NSAIDs to the monoclonal antibodies and the statins. Among the antiangiogenic compounds, a role is suggested for Icon, PPARs, and HDACIs. A new class of drugs is the cannabinoids. The aim of this review was to investigate the new therapeutic hormonal and non-hormonal alternatives to standard treatments.
机译：子宫内膜异位症是一种慢性疾病，应该通过使用药理学治疗和外科手术来开发终身管理计划。子宫内膜异位症的发病机制复杂，并且没有明确地建立。所涉及的机制很多，他们的理解是不断发展的。目前，一线药物通过阻断卵巢功能，产生低生育环境。雌激素分泌和受体活性的阻断和孕酮受体的活化是几种目前药物的主要目标，以及正在开发的主要药物。口服GnRH反生剂，芳香酶抑制剂，SERMS和SPRM是目前用于治疗子宫内膜异位症的激素药物。越来越多的发病机制知识允许开发新的治疗方法。研究最多的是抗炎药，从新的NSAID到单克隆抗体和他汀类药物开始。在抗血管生成化合物中，表明图标，PPAR和HDACIS的作用。一类新的药物是大麻素。本综述的目的是调查新的治疗荷尔蒙和非激素替代品到标准治疗方法。

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