Role of risk stratification and genetics in sudden cardiac death

Rai Vikrant; Agrawal Devendra K.

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Role of risk stratification and genetics in sudden cardiac death

机译：风险分层和遗传在突发心脏死亡中的作用

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Sudden cardiac death (SCD) is a major public health issue due to its increasing incidence in the general population and the difficulty in identifying high-risk individuals. Nearly 300 000 - 350 000 patients in the United States and 4-5 million patients in the world die annually from SCD. Coronary artery disease and advanced heart failure are the main etiology for SCD. Ischemia of any cause precipitates lethal arrhythmias, and ventricular tachycardia and ventricular fibrillation are the most common lethal arrhythmias precipitating SCD. Pulseless electrical activity, bradyarrhythmia, and electromechanical dissociation also result in SCD. Most SCDs occur outside of the hospital setting, so it is difficult to estimate the public burden, which results in overestimating the incidence of SCD. The insufficiency and limited predictive value of various indicators and criteria for SCD result in the increasing incidence. As a result, there is a need to develop better risk stratification criteria and find modifiable variables to decrease the incidence. Primary and secondary prevention and treatment of SCD need further research. This critical review is focused on the etiology, risk factors, prognostic factors, and importance of risk stratification of SCD.

机译：由于其在一般人群的发病率增加以及识别高危人员的困难，突然的心脏死亡（SCD）是一个主要的公共卫生问题。美国近300 000 - 350万名患者和世界上4-500万患者每年从SCD中死亡。冠状动脉疾病和先进的心力衰竭是SCD的主要病因。任何原因的缺血沉淀出致命的心律失常，心室性心动过速和心室颤动是最常见的致死心律失常沉淀SCD。无脉冲电活动，Bradyarrhalthmia和机电解离也导致SCD。大多数SCDS发生在医院环境之外，因此难以估计公共负担，这导致高估SCD的发病率。各种指标的功能不全和有限的预测值和SCD标准导致发病率的增加。结果，需要开发更好的风险分层标准，并找到可修改的变量以降低入射。 SCD的初级和二级预防和治疗需要进一步研究。这项批判性审查专注于SCD风险分层的病因，危险因素，预后因素和重要性。

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《Canadian Journal of Physiology and Pharmacology》 |2017年第3期|共14页
作者
Rai Vikrant; Agrawal Devendra K.;
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作者单位

Creighton Univ Sch Med Dept Clin &

Translat Sci Omaha NE 68178 USA;

Creighton Univ Sch Med Dept Clin &

Translat Sci Omaha NE 68178 USA;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
sudden cardiac death; coronary artery disease; heart failure; arrhythmias; atrial fibrillation; ventricular fibrillation; channelopathies; risk stratification; prevention.;

机译：突然的心脏死亡;冠状动脉疾病;心力衰竭;心律失常;心房颤动;心室颤动;通道分层;风险分层;预防。;

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专利

1. Role of risk stratification and genetics in sudden cardiac death [J] . Rai Vikrant, Agrawal Devendra K. Canadian Journal of Physiology and Pharmacology . 2017,第3期

机译：风险分层和遗传在突发心脏死亡中的作用
2. Risk Stratification for Sudden Cardiac Death Is It Too Late to Establish a Role for Cardiac MRI? [J] . Markman Timothy M., Nazarian Saman Circulation: An Official Journal of the American Heart Association . 2017,第22期

机译：突然心脏病的风险分层是为了建立心脏MRI的作用，为时已晚？
3. The role of nuclear cardiac imaging in risk stratification of sudden cardiac death [J] . Juneau Daniel, Erthal Fernanda, Chow Benjamin J. W., Journal of nuclear cardiology: official publication of the American Society of Nuclear Cardiology . 2016,第6期

机译：核心脏成像在突发心脏死亡风险分层中的作用
4. Risk stratification for Arrhythmic Sudden Cardiac Death in heart failure patients using machine learning techniques [C] . Manis George, Nikolopoulos Stavros, Arsenos Petros, Computing in Cardiology Conference . 2013

机译：使用机器学习技术的心力衰竭患者心律失常性猝死的风险分层
5. The Family Study: Assessment of the Incidence, Etiology, Circumstances and Familial Risk for Sudden Cardiac Death and Aborted Sudden Cardiac Death in Young Individuals. [D] . Allan, Katherine Sarah. 2016

机译：家庭研究：评估年轻人中心源性猝死和堕胎性猝死的发生率，病因，情况和家族风险。
6. Emerging role of genetic analysis for stratification of sudden cardiac death risk in dilated cardiomyopathy: An illustrative case [O] . Jessica Victoria Yao, Stacey Peters, Dominica Zentner, 2020

机译：遗传分析突然心脏死亡风险分层遗传分析的新兴作用：一种说明性案例
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Role of risk stratification and genetics in sudden cardiac death

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